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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHRNA3 All Species: 21.21
Human Site: S416 Identified Species: 42.42
UniProt: P32297 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P32297 NP_000734.2 505 57480 S416 R I K I S N F S A N L T R S S
Chimpanzee Pan troglodytes Q5IS76 494 56903 P415 K R R L S H H P L Q W V V E N
Rhesus Macaque Macaca mulatta XP_001107366 497 56832 T412 S N F S A N L T R S S S S E S
Dog Lupus familis XP_539232 575 65058 S486 R I K I S N F S A N L P R S S
Cat Felis silvestris
Mouse Mus musculus Q8R4G9 499 57091 S410 R V K I S N F S A N L T R S S
Rat Rattus norvegicus P04757 499 56979 S410 R V K I S N F S A N L T R S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513131 979 112159 S890 R I K I S N Y S A N I T Q S S
Chicken Gallus gallus P09481 496 57009 T411 S D F S G N L T R S S S S E S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001921314 508 58116 I410 H H C W K K H I S N M T S E G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P25162 519 60122 R420 D S D N V I P R N L T P E V L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9N587 502 57373 E422 G L N S N R E E S S F T L P R
Sea Urchin Strong. purpuratus XP_786790 570 65253 N460 T L S D D V G N P N I D A P S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 62.3 96.8 79.4 N.A. 91 91 N.A. 46.5 81.1 N.A. 73.6 N.A. 39.8 N.A. 47.7 47.1
Protein Similarity: 100 74.8 97 83.3 N.A. 93.6 93.6 N.A. 49.2 88.3 N.A. 82.4 N.A. 59.5 N.A. 65.9 64
P-Site Identity: 100 6.6 13.3 93.3 N.A. 93.3 93.3 N.A. 80 13.3 N.A. 13.3 N.A. 0 N.A. 6.6 13.3
P-Site Similarity: 100 40 40 93.3 N.A. 100 100 N.A. 100 33.3 N.A. 26.6 N.A. 0 N.A. 33.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 0 42 0 0 0 9 0 0 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 9 9 9 9 0 0 0 0 0 0 9 0 0 0 % D
% Glu: 0 0 0 0 0 0 9 9 0 0 0 0 9 34 0 % E
% Phe: 0 0 17 0 0 0 34 0 0 0 9 0 0 0 0 % F
% Gly: 9 0 0 0 9 0 9 0 0 0 0 0 0 0 9 % G
% His: 9 9 0 0 0 9 17 0 0 0 0 0 0 0 0 % H
% Ile: 0 25 0 42 0 9 0 9 0 0 17 0 0 0 0 % I
% Lys: 9 0 42 0 9 9 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 17 0 9 0 0 17 0 9 9 34 0 9 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % M
% Asn: 0 9 9 9 9 59 0 9 9 59 0 0 0 0 9 % N
% Pro: 0 0 0 0 0 0 9 9 9 0 0 17 0 17 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 9 0 0 9 0 0 % Q
% Arg: 42 9 9 0 0 9 0 9 17 0 0 0 34 0 9 % R
% Ser: 17 9 9 25 50 0 0 42 17 25 17 17 25 42 67 % S
% Thr: 9 0 0 0 0 0 0 17 0 0 9 50 0 0 0 % T
% Val: 0 17 0 0 9 9 0 0 0 0 0 9 9 9 0 % V
% Trp: 0 0 0 9 0 0 0 0 0 0 9 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _