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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HPD All Species: 29.39
Human Site: S197 Identified Species: 46.19
UniProt: P32754 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P32754 NP_002141.1 393 44934 S197 D Q E M V S A S E W Y L K N L
Chimpanzee Pan troglodytes XP_528667 393 44884 S197 D Q E M V S A S E W Y L K N L
Rhesus Macaque Macaca mulatta XP_001096175 393 44868 S197 D Q E M V S A S E W Y L K N L
Dog Lupus familis XP_853422 393 44850 S197 D Q E M V S A S E W Y L K N L
Cat Felis silvestris
Mouse Mus musculus P49429 393 45036 S197 D Q E M Q S A S E W Y L K N L
Rat Rattus norvegicus P32755 393 45094 S197 D Q E M E S A S E W Y L K N L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415144 393 44954 A197 D L Q M V P V A D W Y Q K N L
Frog Xenopus laevis NP_001088204 393 44771 T197 D Q E M V P V T D W Y Q K A L
Zebra Danio Brachydanio rerio Q6TGZ5 397 45192 S198 D D E M V P V S D W Y Q K C L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_730536 380 43278 A196 D L Q M E S V A S W Y E R I L
Honey Bee Apis mellifera XP_001121254 388 44678 A204 D K Q M E L V A K W Y E R C L
Nematode Worm Caenorhab. elegans Q22633 393 44365 V196 D L Q M D S A V Q W Y E K V L
Sea Urchin Strong. purpuratus XP_798672 558 63023 A372 D N E M V S I A D W Y E K N L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93836 445 48797 T239 P E L G P A L T Y V A G F T G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q872T7 412 46010 C226 W N E M V S A C A F Y E Q C L
Conservation
Percent
Protein Identity: 100 99.7 97.1 92.1 N.A. 89.8 89.8 N.A. N.A. 76.5 75 71.7 N.A. 60.5 62.5 60 45.8
Protein Similarity: 100 100 98.9 97.9 N.A. 95.4 96.1 N.A. N.A. 89 86.7 83.6 N.A. 75.8 78.6 73.5 55.5
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 53.3 60 60 N.A. 40 33.3 53.3 66.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 73.3 73.3 66.6 N.A. 60 66.6 66.6 80
Percent
Protein Identity: N.A. N.A. N.A. 27.8 N.A. 51.7
Protein Similarity: N.A. N.A. N.A. 44.2 N.A. 68.4
P-Site Identity: N.A. N.A. N.A. 0 N.A. 46.6
P-Site Similarity: N.A. N.A. N.A. 20 N.A. 60
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 54 27 7 0 7 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 7 0 0 0 0 0 20 0 % C
% Asp: 87 7 0 0 7 0 0 0 27 0 0 0 0 0 0 % D
% Glu: 0 7 67 0 20 0 0 0 40 0 0 34 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 7 0 0 7 0 0 % F
% Gly: 0 0 0 7 0 0 0 0 0 0 0 7 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 7 0 0 0 0 0 0 7 0 % I
% Lys: 0 7 0 0 0 0 0 0 7 0 0 0 74 0 0 % K
% Leu: 0 20 7 0 0 7 7 0 0 0 0 40 0 0 94 % L
% Met: 0 0 0 94 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 14 0 0 0 0 0 0 0 0 0 0 0 54 0 % N
% Pro: 7 0 0 0 7 20 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 47 27 0 7 0 0 0 7 0 0 20 7 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 14 0 0 % R
% Ser: 0 0 0 0 0 67 0 47 7 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 14 0 0 0 0 0 7 0 % T
% Val: 0 0 0 0 60 0 34 7 0 7 0 0 0 7 0 % V
% Trp: 7 0 0 0 0 0 0 0 0 87 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 7 0 94 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _