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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GTF2H1 All Species: 23.03
Human Site: S285 Identified Species: 36.19
UniProt: P32780 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P32780 NP_001135779.1 548 62032 S285 D E G Y G I S S V P S A S N S
Chimpanzee Pan troglodytes XP_001173101 548 62049 S285 D E G Y G I S S V P S A S N S
Rhesus Macaque Macaca mulatta XP_001085569 560 63083 S297 D E G Y G I S S V P S A S N S
Dog Lupus familis XP_534083 548 62056 S285 D E G Y G I S S V P S T S N S
Cat Felis silvestris
Mouse Mus musculus Q9DBA9 547 61833 S284 D E G Y S I S S V P S T S N S
Rat Rattus norvegicus NP_001101955 516 58033 T255 I D E K G L K T M V S L G V K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509381 298 33953 T42 P E G K D R F T I S H M Y A D
Chicken Gallus gallus XP_421013 548 62252 P284 D E G Y G V A P V A S T S N A
Frog Xenopus laevis NP_001080277 532 59910 S255 M D E K G L K S M V S Q G V K
Zebra Danio Brachydanio rerio NP_001004596 550 62395 A285 D E G Y G T A A A P P A S N T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q960E8 585 66321 A285 E E G F G S V A G D R N V V N
Honey Bee Apis mellifera XP_623390 563 64488 P285 D E N Y G N G P S K S D K I S
Nematode Worm Caenorhab. elegans NP_499880 532 61378 T271 E E E M T K M T A E K I Q R K
Sea Urchin Strong. purpuratus XP_798784 547 61424 E286 L S D N T I N E V R C T P S Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q9P5N7 663 73012 F331 N E E N Q G G F R G G N L K D
Conservation
Percent
Protein Identity: 100 99.6 84.8 98.1 N.A. 97 91.2 N.A. 51.2 89.4 79.7 76.7 N.A. 43.5 49 30.4 51.2
Protein Similarity: 100 99.8 88.3 98.9 N.A. 98.3 92.8 N.A. 53.2 94.1 88.5 88.5 N.A. 62.5 70.5 51 73.7
P-Site Identity: 100 100 100 93.3 N.A. 86.6 13.3 N.A. 13.3 60 20 60 N.A. 20 40 6.6 13.3
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 40 N.A. 26.6 80 40 80 N.A. 46.6 40 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 20.5
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 39.8
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 14 14 14 7 0 27 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % C
% Asp: 54 14 7 0 7 0 0 0 0 7 0 7 0 0 14 % D
% Glu: 14 80 27 0 0 0 0 7 0 7 0 0 0 0 0 % E
% Phe: 0 0 0 7 0 0 7 7 0 0 0 0 0 0 0 % F
% Gly: 0 0 60 0 67 7 14 0 7 7 7 0 14 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 7 0 0 0 0 40 0 0 7 0 0 7 0 7 0 % I
% Lys: 0 0 0 20 0 7 14 0 0 7 7 0 7 7 20 % K
% Leu: 7 0 0 0 0 14 0 0 0 0 0 7 7 0 0 % L
% Met: 7 0 0 7 0 0 7 0 14 0 0 7 0 0 0 % M
% Asn: 7 0 7 14 0 7 7 0 0 0 0 14 0 47 7 % N
% Pro: 7 0 0 0 0 0 0 14 0 40 7 0 7 0 0 % P
% Gln: 0 0 0 0 7 0 0 0 0 0 0 7 7 0 0 % Q
% Arg: 0 0 0 0 0 7 0 0 7 7 7 0 0 7 0 % R
% Ser: 0 7 0 0 7 7 34 40 7 7 60 0 47 7 40 % S
% Thr: 0 0 0 0 14 7 0 20 0 0 0 27 0 0 7 % T
% Val: 0 0 0 0 0 7 7 0 47 14 0 0 7 20 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 54 0 0 0 0 0 0 0 0 7 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _