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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTH All Species: 34.55
Human Site: S242 Identified Species: 63.33
UniProt: P32929 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P32929 NP_001893.2 405 44508 S242 R L R F L Q N S L G A V P S P
Chimpanzee Pan troglodytes XP_513486 405 44534 S242 R L R F L Q N S L G A V P S P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537115 405 44312 S242 R L R F L Q N S I G A V P S P
Cat Felis silvestris
Mouse Mus musculus Q8VCN5 398 43549 S241 R L R F L Q N S L G A V P S P
Rat Rattus norvegicus P18757 398 43587 S241 R L R F L Q N S L G A V P S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422542 399 43880 S236 R L K F L Q G S L G A I P S P
Frog Xenopus laevis NP_001087988 398 43874 S235 K L K F L Q N S L G A I P S P
Zebra Danio Brachydanio rerio NP_997769 400 43830 S241 R L K F L Q N S L G A V P S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611352 393 42970 A235 S L K F L Q N A V G I V P S P
Honey Bee Apis mellifera XP_395917 381 41980 G230 R F L Q N A M G I V S S P L D
Nematode Worm Caenorhab. elegans P55216 392 43076 A233 H L F F M Q L A V G A V P S P
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P53780 464 50411 S308 E V Y F L Q N S E G S G L A P
Baker's Yeast Sacchar. cerevisiae P31373 394 42524 A234 R L Q F L Q N A I G A I P S P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 N.A. 89.6 N.A. 84.4 83.6 N.A. N.A. 76.7 75.3 75.5 N.A. 60.2 56 57.5 N.A.
Protein Similarity: 100 99.5 N.A. 94.3 N.A. 90.1 89.6 N.A. N.A. 86.9 87.1 86.1 N.A. 75.3 71.5 73.8 N.A.
P-Site Identity: 100 100 N.A. 93.3 N.A. 100 100 N.A. N.A. 80 80 93.3 N.A. 66.6 13.3 60 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. N.A. 93.3 100 100 N.A. 86.6 26.6 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 36.6 49.6 N.A.
Protein Similarity: N.A. N.A. N.A. 55.8 67.1 N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 73.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 100 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 0 24 0 0 77 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % D
% Glu: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % E
% Phe: 0 8 8 93 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 8 8 0 93 0 8 0 0 0 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 24 0 8 24 0 0 0 % I
% Lys: 8 0 31 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 85 8 0 85 0 8 0 54 0 0 0 8 8 0 % L
% Met: 0 0 0 0 8 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 77 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 93 0 93 % P
% Gln: 0 0 8 8 0 93 0 0 0 0 0 0 0 0 0 % Q
% Arg: 70 0 39 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 0 0 0 0 0 0 70 0 0 16 8 0 85 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 8 0 0 0 0 0 0 16 8 0 62 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _