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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTH
All Species:
33.03
Human Site:
Y253
Identified Species:
60.56
UniProt:
P32929
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P32929
NP_001893.2
405
44508
Y253
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
Chimpanzee
Pan troglodytes
XP_513486
405
44534
Y253
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_537115
405
44312
Y253
V
P
S
P
V
D
C
Y
L
C
N
R
G
L
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCN5
398
43549
Y252
V
P
S
P
F
D
C
Y
L
C
C
R
G
L
K
Rat
Rattus norvegicus
P18757
398
43587
Y252
V
P
S
P
F
D
C
Y
L
C
C
R
G
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422542
399
43880
Y247
I
P
S
P
F
D
C
Y
L
C
N
R
G
L
K
Frog
Xenopus laevis
NP_001087988
398
43874
Y246
I
P
S
P
F
D
C
Y
L
C
N
R
G
L
K
Zebra Danio
Brachydanio rerio
NP_997769
400
43830
Y252
V
P
S
P
F
D
C
Y
M
C
N
R
G
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611352
393
42970
Y246
V
P
S
P
F
D
C
Y
Q
V
N
R
S
L
K
Honey Bee
Apis mellifera
XP_395917
381
41980
V241
S
P
L
D
C
F
L
V
N
R
S
L
K
T
L
Nematode Worm
Caenorhab. elegans
P55216
392
43076
F244
V
P
S
P
F
D
C
F
L
V
N
R
G
L
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P53780
464
50411
W319
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
Baker's Yeast
Sacchar. cerevisiae
P31373
394
42524
W245
I
P
S
P
F
D
A
W
L
T
H
R
G
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
N.A.
89.6
N.A.
84.4
83.6
N.A.
N.A.
76.7
75.3
75.5
N.A.
60.2
56
57.5
N.A.
Protein Similarity:
100
99.5
N.A.
94.3
N.A.
90.1
89.6
N.A.
N.A.
86.9
87.1
86.1
N.A.
75.3
71.5
73.8
N.A.
P-Site Identity:
100
100
N.A.
93.3
N.A.
86.6
86.6
N.A.
N.A.
86.6
86.6
86.6
N.A.
73.3
6.6
80
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
86.6
86.6
N.A.
N.A.
93.3
93.3
93.3
N.A.
73.3
13.3
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.6
49.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.8
67.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
85
0
0
70
16
0
0
0
0
% C
% Asp:
0
0
0
8
0
93
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
70
8
0
8
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
0
0
85
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
24
0
0
0
16
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
93
% K
% Leu:
0
8
8
0
0
0
8
0
77
0
8
8
0
85
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
62
0
0
0
0
% N
% Pro:
0
93
0
93
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
93
0
0
0
% R
% Ser:
8
0
85
0
0
0
0
0
0
0
8
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% T
% Val:
62
0
0
0
8
0
0
8
0
16
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
16
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _