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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CIITA All Species: 16.97
Human Site: S1050 Identified Species: 46.67
UniProt: P33076 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33076 NP_000237.2 1130 123443 S1050 A A S L L R L S L Y N N C I C
Chimpanzee Pan troglodytes Q53B87 1040 115280 C961 N V M L E E L C L E E N H L Q
Rhesus Macaque Macaca mulatta XP_001103518 1130 123636 S1050 A A S L L R L S L Y N N C I C
Dog Lupus familis XP_547128 1104 119761 S1024 A P S L L R L S L Y N N Y I C
Cat Felis silvestris
Mouse Mus musculus P79621 1155 127510 S1075 A K S L L R L S L Y N N C I C
Rat Rattus norvegicus NP_445981 1153 127283 S1073 A K S L L R L S L Y N N C I C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516927 965 106480 M886 L V Q I Q D S M V Q G R R F A
Chicken Gallus gallus XP_425250 824 93504 G745 L D A L S E N G I G D E G A K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001343072 1044 115802 R964 V P S L Q T L R L Y G N A I A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.7 94.3 77.1 N.A. 61.3 61.3 N.A. 37.7 34.2 N.A. 32.1 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 35.2 96.6 84.3 N.A. 72.2 71.4 N.A. 52.1 47.4 N.A. 48.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 26.6 100 86.6 N.A. 93.3 93.3 N.A. 0 6.6 N.A. 46.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 33.3 100 86.6 N.A. 93.3 93.3 N.A. 13.3 26.6 N.A. 46.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 56 23 12 0 0 0 0 0 0 0 0 0 12 12 23 % A
% Cys: 0 0 0 0 0 0 0 12 0 0 0 0 45 0 56 % C
% Asp: 0 12 0 0 0 12 0 0 0 0 12 0 0 0 0 % D
% Glu: 0 0 0 0 12 23 0 0 0 12 12 12 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 12 0 % F
% Gly: 0 0 0 0 0 0 0 12 0 12 23 0 12 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % H
% Ile: 0 0 0 12 0 0 0 0 12 0 0 0 0 67 0 % I
% Lys: 0 23 0 0 0 0 0 0 0 0 0 0 0 0 12 % K
% Leu: 23 0 0 89 56 0 78 0 78 0 0 0 0 12 0 % L
% Met: 0 0 12 0 0 0 0 12 0 0 0 0 0 0 0 % M
% Asn: 12 0 0 0 0 0 12 0 0 0 56 78 0 0 0 % N
% Pro: 0 23 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 12 0 23 0 0 0 0 12 0 0 0 0 12 % Q
% Arg: 0 0 0 0 0 56 0 12 0 0 0 12 12 0 0 % R
% Ser: 0 0 67 0 12 0 12 56 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 % T
% Val: 12 23 0 0 0 0 0 0 12 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 67 0 0 12 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _