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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A2
All Species:
17.27
Human Site:
S101
Identified Species:
31.67
UniProt:
P33402
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33402
NP_000846.1
732
81750
S101
I
S
R
L
T
A
P
S
P
Q
T
I
Q
Q
T
Chimpanzee
Pan troglodytes
XP_522169
734
81883
S103
I
S
R
L
T
A
P
S
P
Q
T
I
Q
Q
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
S115
I
S
R
L
T
A
P
S
P
Q
T
I
Q
Q
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
K101
Q
R
T
L
A
K
H
K
I
E
E
N
R
K
S
Rat
Rattus norvegicus
Q9WVI4
730
81768
T102
L
T
A
P
S
P
Q
T
I
H
M
T
L
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509082
1341
147755
S711
Q
G
Q
E
R
H
P
S
P
Q
T
I
Q
Q
T
Chicken
Gallus gallus
XP_001233954
724
80937
T100
A
P
Q
T
I
R
Q
T
L
Q
R
T
L
Q
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
R62
R
R
V
A
R
R
K
R
V
N
L
D
S
L
G
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
P100
L
S
D
P
S
R
E
P
A
S
P
F
V
C
C
Fruit Fly
Dros. melanogaster
Q07093
676
75644
L102
L
A
D
I
Q
E
L
L
L
K
M
D
E
A
S
Honey Bee
Apis mellifera
NP_001011650
699
78655
T101
K
G
E
E
S
F
P
T
A
R
S
L
E
K
L
Nematode Worm
Caenorhab. elegans
O02298
688
78384
L104
F
L
D
S
L
D
S
L
H
Y
F
I
D
H
V
Sea Urchin
Strong. purpuratus
P16065
1125
126238
V269
I
L
D
S
G
D
Y
V
I
L
G
A
V
V
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
93.6
N.A.
48.3
90.9
N.A.
48.3
88.3
N.A.
55
45.9
34.8
37
28.2
22.3
Protein Similarity:
100
99.7
N.A.
95.8
N.A.
62.9
94.8
N.A.
51.2
93.1
N.A.
67.2
62
53.1
54.3
46
36.7
P-Site Identity:
100
100
N.A.
100
N.A.
6.6
0
N.A.
60
13.3
N.A.
0
6.6
0
6.6
6.6
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
33.3
33.3
N.A.
66.6
26.6
N.A.
0
20
40
53.3
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
8
8
24
0
0
16
0
0
8
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% C
% Asp:
0
0
31
0
0
16
0
0
0
0
0
16
8
0
8
% D
% Glu:
0
0
8
16
0
8
8
0
0
8
8
0
16
0
0
% E
% Phe:
8
0
0
0
0
8
0
0
0
0
8
8
0
0
0
% F
% Gly:
0
16
0
0
8
0
0
0
0
0
8
0
0
0
8
% G
% His:
0
0
0
0
0
8
8
0
8
8
0
0
0
8
0
% H
% Ile:
31
0
0
8
8
0
0
0
24
0
0
39
0
0
0
% I
% Lys:
8
0
0
0
0
8
8
8
0
8
0
0
0
24
0
% K
% Leu:
24
16
0
31
8
0
8
16
16
8
8
8
16
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% N
% Pro:
0
8
0
16
0
8
39
8
31
0
8
0
0
0
0
% P
% Gln:
16
0
16
0
8
0
16
0
0
39
0
0
31
39
0
% Q
% Arg:
8
16
24
0
16
24
0
8
0
8
8
0
8
0
8
% R
% Ser:
0
31
0
16
24
0
8
31
0
8
8
0
8
0
16
% S
% Thr:
0
8
8
8
24
0
0
24
0
0
31
16
0
0
31
% T
% Val:
0
0
8
0
0
0
0
8
8
0
0
0
16
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _