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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A2
All Species:
17.58
Human Site:
S22
Identified Species:
32.22
UniProt:
P33402
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33402
NP_000846.1
732
81750
S22
G
S
D
Y
L
E
T
S
P
E
E
E
G
E
C
Chimpanzee
Pan troglodytes
XP_522169
734
81883
S22
G
S
D
Y
L
E
T
S
P
E
E
E
G
E
C
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
S22
G
S
D
Y
L
E
T
S
P
E
D
E
G
E
C
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
G23
P
F
S
L
L
A
P
G
Q
V
P
K
E
P
T
Rat
Rattus norvegicus
Q9WVI4
730
81768
S22
G
S
D
Y
L
E
T
S
P
E
E
E
G
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509082
1341
147755
C541
L
S
A
I
R
W
S
C
D
W
K
S
G
D
R
Chicken
Gallus gallus
XP_001233954
724
80937
S22
G
S
D
C
P
E
T
S
P
E
E
E
G
E
C
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
K22
C
P
F
T
S
S
A
K
T
N
Q
L
E
H
S
Fruit Fly
Dros. melanogaster
Q07093
676
75644
G23
P
S
V
I
A
E
P
G
G
H
W
A
L
E
D
Honey Bee
Apis mellifera
NP_001011650
699
78655
D22
D
E
Q
T
S
R
G
D
N
D
R
S
R
I
A
Nematode Worm
Caenorhab. elegans
O02298
688
78384
W22
R
K
Y
G
K
D
I
W
E
K
I
V
H
M
S
Sea Urchin
Strong. purpuratus
P16065
1125
126238
I29
R
L
D
F
N
P
T
I
I
N
E
D
R
G
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
93.6
N.A.
48.3
90.9
N.A.
48.3
88.3
N.A.
55
45.9
34.8
37
28.2
22.3
Protein Similarity:
100
99.7
N.A.
95.8
N.A.
62.9
94.8
N.A.
51.2
93.1
N.A.
67.2
62
53.1
54.3
46
36.7
P-Site Identity:
100
100
N.A.
93.3
N.A.
6.6
100
N.A.
13.3
86.6
N.A.
0
0
20
0
0
20
P-Site Similarity:
100
100
N.A.
100
N.A.
13.3
100
N.A.
33.3
86.6
N.A.
0
6.6
20
6.6
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
8
8
0
0
0
0
8
0
0
8
% A
% Cys:
8
0
0
8
0
0
0
8
0
0
0
0
0
0
39
% C
% Asp:
8
0
47
0
0
8
0
8
8
8
8
8
0
8
8
% D
% Glu:
0
8
0
0
0
47
0
0
8
39
39
39
16
47
0
% E
% Phe:
0
8
8
8
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
39
0
0
8
0
0
8
16
8
0
0
0
47
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
8
8
0
% H
% Ile:
0
0
0
16
0
0
8
8
8
0
8
0
0
8
0
% I
% Lys:
0
8
0
0
8
0
0
8
0
8
8
8
0
0
0
% K
% Leu:
8
8
0
8
39
0
0
0
0
0
0
8
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
8
0
0
0
8
16
0
0
0
0
0
% N
% Pro:
16
8
0
0
8
8
16
0
39
0
8
0
0
8
0
% P
% Gln:
0
0
8
0
0
0
0
0
8
0
8
0
0
0
0
% Q
% Arg:
16
0
0
0
8
8
0
0
0
0
8
0
16
0
16
% R
% Ser:
0
54
8
0
16
8
8
39
0
0
0
16
0
0
16
% S
% Thr:
0
0
0
16
0
0
47
0
8
0
0
0
0
0
8
% T
% Val:
0
0
8
0
0
0
0
0
0
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
8
0
8
0
8
8
0
0
0
0
% W
% Tyr:
0
0
8
31
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _