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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A2
All Species:
19.7
Human Site:
S278
Identified Species:
36.11
UniProt:
P33402
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33402
NP_000846.1
732
81750
S278
V
A
N
E
K
L
C
S
D
V
S
N
P
G
N
Chimpanzee
Pan troglodytes
XP_522169
734
81883
S280
V
A
N
E
K
L
C
S
D
V
S
N
P
G
N
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
S292
V
A
S
E
K
L
C
S
D
G
S
N
P
G
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
T245
P
C
F
R
S
D
C
T
E
F
V
N
Q
P
Y
Rat
Rattus norvegicus
Q9WVI4
730
81768
S276
I
E
N
E
K
F
C
S
D
G
S
T
P
S
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509082
1341
147755
S888
V
T
P
D
P
P
G
S
E
G
S
N
P
G
N
Chicken
Gallus gallus
XP_001233954
724
80937
S270
V
T
N
D
K
L
C
S
E
G
T
N
P
G
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
A206
P
S
F
L
C
K
D
A
P
Q
E
N
E
E
T
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
P244
V
D
V
L
M
D
P
P
A
T
K
D
S
I
L
Fruit Fly
Dros. melanogaster
Q07093
676
75644
V248
S
K
T
I
P
E
T
V
Q
R
S
N
S
S
N
Honey Bee
Apis mellifera
NP_001011650
699
78655
F246
P
D
P
Y
N
T
K
F
F
R
Y
R
I
T
P
Nematode Worm
Caenorhab. elegans
O02298
688
78384
N252
F
I
K
K
T
F
P
N
A
M
R
Q
E
T
R
Sea Urchin
Strong. purpuratus
P16065
1125
126238
N579
S
A
I
S
V
I
S
N
A
E
K
Q
Q
I
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
93.6
N.A.
48.3
90.9
N.A.
48.3
88.3
N.A.
55
45.9
34.8
37
28.2
22.3
Protein Similarity:
100
99.7
N.A.
95.8
N.A.
62.9
94.8
N.A.
51.2
93.1
N.A.
67.2
62
53.1
54.3
46
36.7
P-Site Identity:
100
100
N.A.
86.6
N.A.
13.3
60
N.A.
46.6
66.6
N.A.
6.6
6.6
20
0
0
6.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
26.6
66.6
N.A.
60
86.6
N.A.
20
13.3
20
0
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
31
0
0
0
0
0
8
24
0
0
0
0
0
0
% A
% Cys:
0
8
0
0
8
0
47
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
0
16
0
16
8
0
31
0
0
8
0
0
0
% D
% Glu:
0
8
0
31
0
8
0
0
24
8
8
0
16
8
0
% E
% Phe:
8
0
16
0
0
16
0
8
8
8
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
8
0
0
31
0
0
0
39
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
8
8
0
8
0
0
0
0
0
0
8
16
0
% I
% Lys:
0
8
8
8
39
8
8
0
0
0
16
0
0
0
0
% K
% Leu:
0
0
0
16
0
31
0
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
31
0
8
0
0
16
0
0
0
62
0
0
54
% N
% Pro:
24
0
16
0
16
8
16
8
8
0
0
0
47
8
8
% P
% Gln:
0
0
0
0
0
0
0
0
8
8
0
16
16
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
16
8
8
0
0
8
% R
% Ser:
16
8
8
8
8
0
8
47
0
0
47
0
16
16
0
% S
% Thr:
0
16
8
0
8
8
8
8
0
8
8
8
0
16
8
% T
% Val:
47
0
8
0
8
0
0
8
0
16
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _