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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A2
All Species:
22.12
Human Site:
S310
Identified Species:
40.56
UniProt:
P33402
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33402
NP_000846.1
732
81750
S310
K
N
L
P
Q
G
T
S
Q
V
P
A
D
L
R
Chimpanzee
Pan troglodytes
XP_522169
734
81883
S312
K
N
L
P
Q
G
T
S
Q
V
P
A
D
L
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
S324
K
N
L
A
Q
G
T
S
H
V
P
A
D
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
I277
K
P
Q
S
S
L
V
I
P
A
S
L
F
C
K
Rat
Rattus norvegicus
Q9WVI4
730
81768
S308
K
N
I
P
Q
G
T
S
Q
I
P
T
D
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509082
1341
147755
S920
Q
T
F
P
P
G
T
S
L
V
P
A
D
L
R
Chicken
Gallus gallus
XP_001233954
724
80937
S302
K
A
L
P
S
G
T
S
H
S
P
L
D
L
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
M238
D
P
T
V
G
V
A
M
P
G
L
I
R
A
A
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
L276
K
S
L
S
P
S
P
L
R
A
T
S
A
G
T
Fruit Fly
Dros. melanogaster
Q07093
676
75644
L280
H
F
I
M
N
E
Q
L
E
L
V
Q
L
G
R
Honey Bee
Apis mellifera
NP_001011650
699
78655
S278
T
S
L
F
R
P
L
S
S
E
A
T
D
L
R
Nematode Worm
Caenorhab. elegans
O02298
688
78384
S284
S
I
K
Y
Y
K
N
S
L
F
V
F
R
L
K
Sea Urchin
Strong. purpuratus
P16065
1125
126238
R611
K
N
H
I
D
L
T
R
A
V
R
T
E
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
93.6
N.A.
48.3
90.9
N.A.
48.3
88.3
N.A.
55
45.9
34.8
37
28.2
22.3
Protein Similarity:
100
99.7
N.A.
95.8
N.A.
62.9
94.8
N.A.
51.2
93.1
N.A.
67.2
62
53.1
54.3
46
36.7
P-Site Identity:
100
100
N.A.
86.6
N.A.
6.6
80
N.A.
66.6
66.6
N.A.
0
13.3
6.6
33.3
13.3
33.3
P-Site Similarity:
100
100
N.A.
86.6
N.A.
13.3
93.3
N.A.
73.3
66.6
N.A.
0
33.3
26.6
46.6
20
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
0
8
0
8
16
8
31
8
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
8
0
0
0
8
0
0
0
0
0
0
0
54
0
0
% D
% Glu:
0
0
0
0
0
8
0
0
8
8
0
0
8
0
0
% E
% Phe:
0
8
8
8
0
0
0
0
0
8
0
8
8
0
0
% F
% Gly:
0
0
0
0
8
47
0
0
0
8
0
0
0
16
0
% G
% His:
8
0
8
0
0
0
0
0
16
0
0
0
0
0
0
% H
% Ile:
0
8
16
8
0
0
0
8
0
8
0
8
0
0
0
% I
% Lys:
62
0
8
0
0
8
0
0
0
0
0
0
0
0
24
% K
% Leu:
0
0
47
0
0
16
8
16
16
8
8
16
8
70
0
% L
% Met:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
39
0
0
8
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
16
0
39
16
8
8
0
16
0
47
0
0
0
0
% P
% Gln:
8
0
8
0
31
0
8
0
24
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
8
8
0
8
0
16
0
62
% R
% Ser:
8
16
0
16
16
8
0
62
8
8
8
8
0
0
0
% S
% Thr:
8
8
8
0
0
0
54
0
0
0
8
24
0
0
8
% T
% Val:
0
0
0
8
0
8
8
0
0
39
16
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _