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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GUCY1A2 All Species: 19.7
Human Site: S39 Identified Species: 36.11
UniProt: P33402 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33402 NP_000846.1 732 81750 S39 S R L C W N G S R S P P G P L
Chimpanzee Pan troglodytes XP_522169 734 81883 S39 S R L C W N G S R S P P G P L
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536590 746 83063 S39 A R L C W N G S Q R P P G P P
Cat Felis silvestris
Mouse Mus musculus Q9ERL9 691 77555 C40 V A G G S E G C Q A T L P I C
Rat Rattus norvegicus Q9WVI4 730 81768 S39 S K L C W N G S R S P P G P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509082 1341 147755 T558 A E I R K N L T L T D L T Y C
Chicken Gallus gallus XP_001233954 724 80937 S39 S R L C W N G S R S P P G P A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002667138 626 69572
Tiger Blowfish Takifugu rubipres NP_001027855 675 75480 L39 L S K D V A H L P T S K D V R
Fruit Fly Dros. melanogaster Q07093 676 75644 L40 L S D D A L T L T H L Q M A I
Honey Bee Apis mellifera NP_001011650 699 78655 S39 G R D D G G K S R Q S S F E V
Nematode Worm Caenorhab. elegans O02298 688 78384 I39 E L G T E S E I A H Y Y N D D
Sea Urchin Strong. purpuratus P16065 1125 126238 E46 I H V G L L A E W T T A D G D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 N.A. 93.6 N.A. 48.3 90.9 N.A. 48.3 88.3 N.A. 55 45.9 34.8 37 28.2 22.3
Protein Similarity: 100 99.7 N.A. 95.8 N.A. 62.9 94.8 N.A. 51.2 93.1 N.A. 67.2 62 53.1 54.3 46 36.7
P-Site Identity: 100 100 N.A. 73.3 N.A. 6.6 86.6 N.A. 6.6 93.3 N.A. 0 0 0 20 0 0
P-Site Similarity: 100 100 N.A. 86.6 N.A. 20 93.3 N.A. 33.3 93.3 N.A. 0 6.6 6.6 26.6 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 0 0 8 8 8 0 8 8 0 8 0 8 8 % A
% Cys: 0 0 0 39 0 0 0 8 0 0 0 0 0 0 16 % C
% Asp: 0 0 16 24 0 0 0 0 0 0 8 0 16 8 16 % D
% Glu: 8 8 0 0 8 8 8 8 0 0 0 0 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % F
% Gly: 8 0 16 16 8 8 47 0 0 0 0 0 39 8 0 % G
% His: 0 8 0 0 0 0 8 0 0 16 0 0 0 0 0 % H
% Ile: 8 0 8 0 0 0 0 8 0 0 0 0 0 8 8 % I
% Lys: 0 8 8 0 8 0 8 0 0 0 0 8 0 0 0 % K
% Leu: 16 8 39 0 8 16 8 16 8 0 8 16 0 0 16 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 0 0 0 47 0 0 0 0 0 0 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 8 0 39 39 8 39 16 % P
% Gln: 0 0 0 0 0 0 0 0 16 8 0 8 0 0 0 % Q
% Arg: 0 39 0 8 0 0 0 0 39 8 0 0 0 0 8 % R
% Ser: 31 16 0 0 8 8 0 47 0 31 16 8 0 0 0 % S
% Thr: 0 0 0 8 0 0 8 8 8 24 16 0 8 0 0 % T
% Val: 8 0 8 0 8 0 0 0 0 0 0 0 0 8 8 % V
% Trp: 0 0 0 0 39 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 8 8 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _