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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A2
All Species:
21.52
Human Site:
S397
Identified Species:
39.44
UniProt:
P33402
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33402
NP_000846.1
732
81750
S397
T
K
P
E
A
S
G
S
E
N
K
D
K
V
M
Chimpanzee
Pan troglodytes
XP_522169
734
81883
S399
T
K
P
E
A
S
G
S
E
N
K
D
K
V
M
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
T411
T
K
P
E
A
S
G
T
E
N
K
D
K
V
M
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
V363
S
V
K
K
S
S
R
V
M
D
L
K
G
Q
M
Rat
Rattus norvegicus
Q9WVI4
730
81768
T395
T
K
P
E
A
S
G
T
D
N
E
D
K
V
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509082
1341
147755
S1007
T
R
A
E
A
S
G
S
E
D
R
D
K
V
M
Chicken
Gallus gallus
XP_001233954
724
80937
S389
T
R
L
E
D
S
D
S
E
N
K
D
K
V
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
G324
S
P
L
D
L
R
I
G
L
S
T
F
C
R
A
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
A365
I
K
R
G
V
S
T
A
D
N
T
L
M
D
L
Fruit Fly
Dros. melanogaster
Q07093
676
75644
F366
P
E
S
N
S
L
L
F
I
G
S
P
F
L
D
Honey Bee
Apis mellifera
NP_001011650
699
78655
D367
L
Q
R
P
Q
D
V
D
K
Y
P
A
E
G
L
Nematode Worm
Caenorhab. elegans
O02298
688
78384
E373
V
E
L
N
R
T
L
E
E
T
T
K
K
L
K
Sea Urchin
Strong. purpuratus
P16065
1125
126238
C699
G
H
L
K
S
S
N
C
V
V
D
N
R
W
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
93.6
N.A.
48.3
90.9
N.A.
48.3
88.3
N.A.
55
45.9
34.8
37
28.2
22.3
Protein Similarity:
100
99.7
N.A.
95.8
N.A.
62.9
94.8
N.A.
51.2
93.1
N.A.
67.2
62
53.1
54.3
46
36.7
P-Site Identity:
100
100
N.A.
93.3
N.A.
13.3
80
N.A.
73.3
73.3
N.A.
0
20
0
0
13.3
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
40
100
N.A.
93.3
80
N.A.
20
40
20
26.6
33.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
39
0
0
8
0
0
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
8
8
8
8
8
16
16
8
47
0
8
8
% D
% Glu:
0
16
0
47
0
0
0
8
47
0
8
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
8
8
0
0
% F
% Gly:
8
0
0
8
0
0
39
8
0
8
0
0
8
8
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% I
% Lys:
0
39
8
16
0
0
0
0
8
0
31
16
54
0
8
% K
% Leu:
8
0
31
0
8
8
16
0
8
0
8
8
0
16
16
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
54
% M
% Asn:
0
0
0
16
0
0
8
0
0
47
0
8
0
0
0
% N
% Pro:
8
8
31
8
0
0
0
0
0
0
8
8
0
0
0
% P
% Gln:
0
8
0
0
8
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
16
16
0
8
8
8
0
0
0
8
0
8
8
0
% R
% Ser:
16
0
8
0
24
70
0
31
0
8
8
0
0
0
0
% S
% Thr:
47
0
0
0
0
8
8
16
0
8
24
0
0
0
0
% T
% Val:
8
8
0
0
8
0
8
8
8
8
0
0
0
47
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _