Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GUCY1A2 All Species: 18.18
Human Site: S7 Identified Species: 33.33
UniProt: P33402 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33402 NP_000846.1 732 81750 S7 _ M S R R K I S S E S F S S L
Chimpanzee Pan troglodytes XP_522169 734 81883 S7 _ M S R R K I S S E S F S S L
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536590 746 83063 S7 _ M S R R K I S S E S F S S L
Cat Felis silvestris
Mouse Mus musculus Q9ERL9 691 77555 D8 M F C R K F K D L K I T G E C
Rat Rattus norvegicus Q9WVI4 730 81768 S7 _ M S R R K I S S E S F S S L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509082 1341 147755 L526 A L R G R R V L G L P P S V S
Chicken Gallus gallus XP_001233954 724 80937 S7 _ M S R R K I S S E S F S S L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002667138 626 69572
Tiger Blowfish Takifugu rubipres NP_001027855 675 75480 K7 _ M F C T K L K E L K I S G E
Fruit Fly Dros. melanogaster Q07093 676 75644 R8 M A C P F F R R A D S L T R Q
Honey Bee Apis mellifera NP_001011650 699 78655 R7 _ M A C P F S R D L S K P G C
Nematode Worm Caenorhab. elegans O02298 688 78384 E7 _ M F G W I H E S F R Q L V T
Sea Urchin Strong. purpuratus P16065 1125 126238 F14 L F L F M V A F T I T M V I A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 N.A. 93.6 N.A. 48.3 90.9 N.A. 48.3 88.3 N.A. 55 45.9 34.8 37 28.2 22.3
Protein Similarity: 100 99.7 N.A. 95.8 N.A. 62.9 94.8 N.A. 51.2 93.1 N.A. 67.2 62 53.1 54.3 46 36.7
P-Site Identity: 100 100 N.A. 100 N.A. 6.6 100 N.A. 13.3 100 N.A. 0 21.4 6.6 14.2 14.2 0
P-Site Similarity: 100 100 N.A. 100 N.A. 20 100 N.A. 33.3 100 N.A. 0 28.5 26.6 21.4 14.2 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 0 0 8 0 8 0 0 0 0 0 8 % A
% Cys: 0 0 16 16 0 0 0 0 0 0 0 0 0 0 16 % C
% Asp: 0 0 0 0 0 0 0 8 8 8 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 8 8 39 0 0 0 8 8 % E
% Phe: 0 16 16 8 8 24 0 8 0 8 0 39 0 0 0 % F
% Gly: 0 0 0 16 0 0 0 0 8 0 0 0 8 16 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 39 0 0 8 8 8 0 8 0 % I
% Lys: 0 0 0 0 8 47 8 8 0 8 8 8 0 0 0 % K
% Leu: 8 8 8 0 0 0 8 8 8 24 0 8 8 0 39 % L
% Met: 16 62 0 0 8 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 8 8 0 0 0 0 0 8 8 8 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % Q
% Arg: 0 0 8 47 47 8 8 16 0 0 8 0 0 8 0 % R
% Ser: 0 0 39 0 0 0 8 39 47 0 54 0 54 39 8 % S
% Thr: 0 0 0 0 8 0 0 0 8 0 8 8 8 0 8 % T
% Val: 0 0 0 0 0 8 8 0 0 0 0 0 8 16 0 % V
% Trp: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 62 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _