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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A2
All Species:
17.58
Human Site:
T354
Identified Species:
32.22
UniProt:
P33402
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33402
NP_000846.1
732
81750
T354
R
K
Q
L
R
C
D
T
H
K
V
L
K
F
E
Chimpanzee
Pan troglodytes
XP_522169
734
81883
T356
R
K
Q
L
R
C
D
T
H
K
V
L
K
F
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
T368
R
K
Q
L
R
C
D
T
H
K
V
L
K
F
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
F320
D
F
Q
G
K
P
N
F
E
E
F
F
E
I
L
Rat
Rattus norvegicus
Q9WVI4
730
81768
N352
R
K
Q
L
R
C
D
N
H
K
V
L
K
F
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509082
1341
147755
T964
R
K
Q
L
R
C
E
T
H
K
A
L
N
F
E
Chicken
Gallus gallus
XP_001233954
724
80937
T346
R
K
Q
L
R
C
D
T
H
K
T
L
K
F
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
S281
S
A
D
S
S
P
S
S
S
P
S
P
P
S
S
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
L322
R
L
T
R
K
D
G
L
R
R
P
A
T
F
Q
Fruit Fly
Dros. melanogaster
Q07093
676
75644
I323
L
T
M
K
F
R
D
I
V
R
R
T
Y
T
P
Honey Bee
Apis mellifera
NP_001011650
699
78655
R324
I
F
G
H
H
L
N
R
L
G
R
E
I
S
T
Nematode Worm
Caenorhab. elegans
O02298
688
78384
V330
L
Y
M
C
S
V
N
V
T
T
V
R
E
L
I
Sea Urchin
Strong. purpuratus
P16065
1125
126238
I656
A
K
G
S
L
Q
D
I
L
E
N
D
D
I
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
93.6
N.A.
48.3
90.9
N.A.
48.3
88.3
N.A.
55
45.9
34.8
37
28.2
22.3
Protein Similarity:
100
99.7
N.A.
95.8
N.A.
62.9
94.8
N.A.
51.2
93.1
N.A.
67.2
62
53.1
54.3
46
36.7
P-Site Identity:
100
100
N.A.
100
N.A.
6.6
93.3
N.A.
80
86.6
N.A.
0
13.3
6.6
0
6.6
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
33.3
93.3
N.A.
86.6
93.3
N.A.
6.6
33.3
13.3
6.6
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
0
0
0
0
8
8
0
0
0
% A
% Cys:
0
0
0
8
0
47
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
0
8
54
0
0
0
0
8
8
0
0
% D
% Glu:
0
0
0
0
0
0
8
0
8
16
0
8
16
0
39
% E
% Phe:
0
16
0
0
8
0
0
8
0
0
8
8
0
54
0
% F
% Gly:
0
0
16
8
0
0
8
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
8
8
0
0
0
47
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
16
0
0
0
0
8
16
8
% I
% Lys:
0
54
0
8
16
0
0
0
0
47
0
0
39
0
8
% K
% Leu:
16
8
0
47
8
8
0
8
16
0
0
47
0
8
8
% L
% Met:
0
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
24
8
0
0
8
0
8
0
0
% N
% Pro:
0
0
0
0
0
16
0
0
0
8
8
8
8
0
8
% P
% Gln:
0
0
54
0
0
8
0
0
0
0
0
0
0
0
16
% Q
% Arg:
54
0
0
8
47
8
0
8
8
16
16
8
0
0
0
% R
% Ser:
8
0
0
16
16
0
8
8
8
0
8
0
0
16
8
% S
% Thr:
0
8
8
0
0
0
0
39
8
8
8
8
8
8
8
% T
% Val:
0
0
0
0
0
8
0
8
8
0
39
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _