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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A2
All Species:
32.42
Human Site:
T605
Identified Species:
59.44
UniProt:
P33402
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33402
NP_000846.1
732
81750
T605
E
L
S
E
E
V
L
T
P
D
G
R
P
I
Q
Chimpanzee
Pan troglodytes
XP_522169
734
81883
T607
E
L
S
E
E
V
L
T
P
D
G
R
P
I
Q
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
T619
E
L
S
E
E
V
L
T
P
D
G
R
P
I
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
S565
E
L
S
N
E
V
M
S
P
H
G
E
P
I
K
Rat
Rattus norvegicus
Q9WVI4
730
81768
T603
E
L
S
E
E
V
L
T
P
D
G
R
P
I
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509082
1341
147755
T1215
E
L
S
E
E
V
L
T
P
D
G
R
P
I
Q
Chicken
Gallus gallus
XP_001233954
724
80937
T597
E
L
S
E
E
V
L
T
P
D
G
S
P
I
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
I502
T
V
D
L
L
Y
S
I
F
P
G
D
V
A
Q
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
E549
G
G
L
H
K
E
S
E
T
H
A
V
Q
V
A
Fruit Fly
Dros. melanogaster
Q07093
676
75644
T550
D
A
C
S
K
H
I
T
H
D
G
E
Q
I
K
Honey Bee
Apis mellifera
NP_001011650
699
78655
T575
Q
A
C
S
H
H
L
T
H
K
G
K
P
I
R
Nematode Worm
Caenorhab. elegans
O02298
688
78384
S563
I
Q
C
K
I
H
V
S
E
T
G
K
L
N
G
Sea Urchin
Strong. purpuratus
P16065
1125
126238
H1001
V
K
G
F
I
V
P
H
K
P
E
V
F
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
93.6
N.A.
48.3
90.9
N.A.
48.3
88.3
N.A.
55
45.9
34.8
37
28.2
22.3
Protein Similarity:
100
99.7
N.A.
95.8
N.A.
62.9
94.8
N.A.
51.2
93.1
N.A.
67.2
62
53.1
54.3
46
36.7
P-Site Identity:
100
100
N.A.
100
N.A.
60
100
N.A.
100
86.6
N.A.
13.3
0
26.6
33.3
6.6
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
80
100
N.A.
100
93.3
N.A.
20
13.3
53.3
53.3
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
0
0
0
0
0
8
0
0
8
8
% A
% Cys:
0
0
24
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
0
0
0
0
0
54
0
8
0
0
0
% D
% Glu:
54
0
0
47
54
8
0
8
8
0
8
16
0
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
8
0
0
0
8
0
0
% F
% Gly:
8
8
8
0
0
0
0
0
0
0
85
0
0
0
8
% G
% His:
0
0
0
8
8
24
0
8
16
16
0
0
0
0
0
% H
% Ile:
8
0
0
0
16
0
8
8
0
0
0
0
0
70
0
% I
% Lys:
0
8
0
8
16
0
0
0
8
8
0
16
0
0
31
% K
% Leu:
0
54
8
8
8
0
54
0
0
0
0
0
8
8
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
8
0
54
16
0
0
62
0
0
% P
% Gln:
8
8
0
0
0
0
0
0
0
0
0
0
16
0
47
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
39
0
0
8
% R
% Ser:
0
0
54
16
0
0
16
16
0
0
0
8
0
0
0
% S
% Thr:
8
0
0
0
0
0
0
62
8
8
0
0
0
0
0
% T
% Val:
8
8
0
0
0
62
8
0
0
0
0
16
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _