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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A2
All Species:
18.48
Human Site:
T701
Identified Species:
33.89
UniProt:
P33402
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33402
NP_000846.1
732
81750
T701
C
Y
F
L
E
V
R
T
G
P
K
P
P
K
P
Chimpanzee
Pan troglodytes
XP_522169
734
81883
T703
C
Y
F
L
E
V
R
T
G
P
K
P
P
K
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
T715
C
Y
F
L
E
V
R
T
G
P
K
Q
P
K
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
H661
C
H
F
L
D
A
Y
H
H
Q
G
P
N
S
K
Rat
Rattus norvegicus
Q9WVI4
730
81768
T699
C
Y
F
L
E
L
R
T
G
P
K
P
P
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509082
1341
147755
T1310
I
C
Y
F
L
E
V
T
T
G
P
K
Q
P
K
Chicken
Gallus gallus
XP_001233954
724
80937
S693
C
Y
F
L
E
V
R
S
G
Q
K
Q
P
K
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
L596
S
H
A
K
P
I
A
L
M
A
L
K
M
M
E
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
R643
P
E
F
V
F
I
P
R
R
R
Q
E
L
P
A
Fruit Fly
Dros. melanogaster
Q07093
676
75644
E646
T
E
T
C
Y
F
L
E
S
F
R
N
P
A
L
Honey Bee
Apis mellifera
NP_001011650
699
78655
N669
E
G
T
S
Y
F
L
N
D
Y
K
H
K
D
V
Nematode Worm
Caenorhab. elegans
O02298
688
78384
N658
Q
N
N
H
N
N
N
N
N
T
H
H
S
G
R
Sea Urchin
Strong. purpuratus
P16065
1125
126238
S1095
W
L
L
G
Q
D
P
S
Y
K
I
T
K
V
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
93.6
N.A.
48.3
90.9
N.A.
48.3
88.3
N.A.
55
45.9
34.8
37
28.2
22.3
Protein Similarity:
100
99.7
N.A.
95.8
N.A.
62.9
94.8
N.A.
51.2
93.1
N.A.
67.2
62
53.1
54.3
46
36.7
P-Site Identity:
100
100
N.A.
93.3
N.A.
26.6
93.3
N.A.
6.6
80
N.A.
0
6.6
6.6
6.6
0
0
P-Site Similarity:
100
100
N.A.
93.3
N.A.
40
100
N.A.
13.3
86.6
N.A.
13.3
26.6
13.3
6.6
0
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
8
8
0
0
8
0
0
0
8
8
% A
% Cys:
47
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
8
0
0
8
0
0
0
0
8
0
% D
% Glu:
8
16
0
0
39
8
0
8
0
0
0
8
0
0
8
% E
% Phe:
0
0
54
8
8
16
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
8
0
8
0
0
0
0
39
8
8
0
0
8
0
% G
% His:
0
16
0
8
0
0
0
8
8
0
8
16
0
0
0
% H
% Ile:
8
0
0
0
0
16
0
0
0
0
8
0
0
0
0
% I
% Lys:
0
0
0
8
0
0
0
0
0
8
47
16
16
39
24
% K
% Leu:
0
8
8
47
8
8
16
8
0
0
8
0
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
8
8
0
% M
% Asn:
0
8
8
0
8
8
8
16
8
0
0
8
8
0
0
% N
% Pro:
8
0
0
0
8
0
16
0
0
31
8
31
47
16
39
% P
% Gln:
8
0
0
0
8
0
0
0
0
16
8
16
8
0
0
% Q
% Arg:
0
0
0
0
0
0
39
8
8
8
8
0
0
0
8
% R
% Ser:
8
0
0
8
0
0
0
16
8
0
0
0
8
8
0
% S
% Thr:
8
0
16
0
0
0
0
39
8
8
0
8
0
0
0
% T
% Val:
0
0
0
8
0
31
8
0
0
0
0
0
0
8
8
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
39
8
0
16
0
8
0
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _