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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A2
All Species:
30.91
Human Site:
Y663
Identified Species:
56.67
UniProt:
P33402
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33402
NP_000846.1
732
81750
Y663
I
N
V
S
P
T
T
Y
Q
L
L
K
R
E
E
Chimpanzee
Pan troglodytes
XP_522169
734
81883
Y665
I
N
V
S
P
T
T
Y
Q
L
L
K
R
E
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
Y677
I
N
V
S
P
T
T
Y
Q
L
L
K
R
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
Y623
I
N
V
S
P
T
T
Y
R
L
L
K
D
C
P
Rat
Rattus norvegicus
Q9WVI4
730
81768
Y661
I
N
I
S
P
T
T
Y
Q
L
L
K
R
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509082
1341
147755
Y1273
I
N
V
S
P
T
T
Y
Q
L
L
K
R
E
E
Chicken
Gallus gallus
XP_001233954
724
80937
Y655
I
N
V
S
P
T
T
Y
Q
L
L
K
K
E
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
Y560
E
L
Y
T
R
F
D
Y
Q
C
G
I
L
D
V
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
V607
Y
C
L
F
G
N
N
V
T
L
A
N
K
F
E
Fruit Fly
Dros. melanogaster
Q07093
676
75644
K608
I
N
V
S
P
T
T
K
D
W
L
T
K
H
E
Honey Bee
Apis mellifera
NP_001011650
699
78655
Y633
I
H
V
S
P
T
T
Y
I
L
L
K
Y
P
I
Nematode Worm
Caenorhab. elegans
O02298
688
78384
D621
R
S
G
E
Q
T
I
D
G
Y
M
E
L
H
D
Sea Urchin
Strong. purpuratus
P16065
1125
126238
K1059
I
H
V
S
P
W
C
K
Q
V
L
D
K
L
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
N.A.
93.6
N.A.
48.3
90.9
N.A.
48.3
88.3
N.A.
55
45.9
34.8
37
28.2
22.3
Protein Similarity:
100
99.7
N.A.
95.8
N.A.
62.9
94.8
N.A.
51.2
93.1
N.A.
67.2
62
53.1
54.3
46
36.7
P-Site Identity:
100
100
N.A.
100
N.A.
73.3
86.6
N.A.
100
93.3
N.A.
13.3
13.3
60
66.6
6.6
40
P-Site Similarity:
100
100
N.A.
100
N.A.
80
100
N.A.
100
100
N.A.
26.6
26.6
66.6
73.3
33.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
8
0
0
8
0
0
0
8
0
% C
% Asp:
0
0
0
0
0
0
8
8
8
0
0
8
8
8
16
% D
% Glu:
8
0
0
8
0
0
0
0
0
0
0
8
0
47
54
% E
% Phe:
0
0
0
8
0
8
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
8
0
8
0
0
0
8
0
8
0
0
0
8
% G
% His:
0
16
0
0
0
0
0
0
0
0
0
0
0
16
0
% H
% Ile:
77
0
8
0
0
0
8
0
8
0
0
8
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
16
0
0
0
62
31
0
0
% K
% Leu:
0
8
8
0
0
0
0
0
0
70
77
0
16
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
62
0
0
0
8
8
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
0
77
0
0
0
0
0
0
0
0
8
8
% P
% Gln:
0
0
0
0
8
0
0
0
62
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
8
0
0
0
8
0
0
0
39
0
0
% R
% Ser:
0
8
0
77
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
8
0
77
70
0
8
0
0
8
0
0
0
% T
% Val:
0
0
70
0
0
0
0
8
0
8
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% W
% Tyr:
8
0
8
0
0
0
0
70
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _