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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTK
All Species:
27.27
Human Site:
S781
Identified Species:
50
UniProt:
P33981
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33981
NP_003309.2
857
97072
S781
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
Chimpanzee
Pan troglodytes
XP_001146752
857
97034
S781
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
Rhesus Macaque
Macaca mulatta
XP_001111082
778
87619
D703
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
Dog
Lupus familis
XP_539016
855
96614
S778
R
D
P
K
Q
R
I
S
I
P
D
L
L
A
H
Cat
Felis silvestris
Mouse
Mus musculus
P35761
856
96192
S780
R
N
P
K
E
R
I
S
I
P
E
L
L
T
H
Rat
Rattus norvegicus
NP_001101642
835
94323
S759
R
N
P
K
E
R
I
S
I
P
E
L
L
A
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512474
935
104827
S792
R
N
P
K
D
R
I
S
I
P
E
L
L
T
H
Chicken
Gallus gallus
XP_419867
879
99691
S801
P
K
Q
R
I
S
V
S
E
L
L
V
H
P
Y
Frog
Xenopus laevis
NP_001082090
882
99060
A804
P
K
E
R
I
S
I
A
E
L
L
V
H
P
Y
Zebra Danio
Brachydanio rerio
Q8AYG3
982
109993
S906
R
N
P
R
E
R
I
S
I
A
E
L
L
D
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002301009
818
91361
V739
H
P
F
L
V
P
P
V
P
T
Q
P
S
V
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565160
777
86358
Q702
P
P
I
P
H
E
P
Q
V
K
T
I
K
L
F
Baker's Yeast
Sacchar. cerevisiae
P54199
764
86809
A689
N
E
K
I
P
K
S
A
I
E
L
M
K
A
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
85.7
87.4
N.A.
74.3
76.9
N.A.
64.2
61
52.8
41.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
87.7
92.6
N.A.
84.8
85.6
N.A.
73.6
74.5
68.4
57
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
93.3
N.A.
80
86.6
N.A.
80
6.6
6.6
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
26.6
100
N.A.
93.3
100
N.A.
86.6
33.3
33.3
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.1
N.A.
N.A.
22.9
22.7
N.A.
Protein Similarity:
40.2
N.A.
N.A.
42.3
44.5
N.A.
P-Site Identity:
0
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
13.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
16
0
8
0
0
0
39
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% C
% Asp:
0
24
8
0
8
0
0
8
0
0
16
0
0
8
0
% D
% Glu:
0
8
8
0
24
16
0
0
16
8
47
0
0
0
0
% E
% Phe:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
8
0
0
0
8
0
0
0
0
0
0
0
16
0
54
% H
% Ile:
0
0
8
16
16
0
62
0
62
0
0
8
0
0
0
% I
% Lys:
0
16
8
47
0
8
8
0
0
8
0
0
16
8
0
% K
% Leu:
0
0
0
8
0
0
0
0
8
16
24
54
62
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
8
31
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
24
24
54
8
16
8
16
0
8
47
0
8
0
16
0
% P
% Gln:
0
0
8
0
24
0
0
8
0
8
8
0
0
0
0
% Q
% Arg:
54
0
0
24
0
54
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
16
8
62
0
0
0
0
8
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
0
8
8
0
0
16
0
% T
% Val:
0
0
0
0
8
0
8
8
8
0
0
24
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _