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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTK
All Species:
9.09
Human Site:
T235
Identified Species:
16.67
UniProt:
P33981
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33981
NP_003309.2
857
97072
T235
S
C
D
S
R
G
Q
T
T
K
A
R
F
L
Y
Chimpanzee
Pan troglodytes
XP_001146752
857
97034
T235
S
C
D
S
R
G
Q
T
T
K
A
R
F
L
Y
Rhesus Macaque
Macaca mulatta
XP_001111082
778
87619
S196
L
Q
K
K
Q
L
L
S
E
E
E
K
K
T
L
Dog
Lupus familis
XP_539016
855
96614
G233
N
I
S
C
D
S
R
G
Q
T
T
K
A
R
F
Cat
Felis silvestris
Mouse
Mus musculus
P35761
856
96192
A231
S
C
E
S
R
G
Q
A
G
A
A
R
V
L
Y
Rat
Rattus norvegicus
NP_001101642
835
94323
S213
T
A
Q
E
S
F
S
S
S
L
G
N
L
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512474
935
104827
G238
S
G
G
L
S
T
N
G
A
R
F
L
N
G
E
Chicken
Gallus gallus
XP_419867
879
99691
F239
L
C
G
S
S
R
E
F
V
R
L
S
V
L
L
Frog
Xenopus laevis
NP_001082090
882
99060
Y237
K
I
E
S
P
E
E
Y
S
V
K
T
R
F
S
Zebra Danio
Brachydanio rerio
Q8AYG3
982
109993
T297
L
C
S
S
K
K
G
T
P
D
G
D
S
Y
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002301009
818
91361
N210
N
D
E
T
K
Q
Q
N
F
Q
N
M
E
S
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565160
777
86358
P195
G
S
K
H
Q
N
L
P
S
V
D
S
E
V
S
Baker's Yeast
Sacchar. cerevisiae
P54199
764
86809
V182
T
N
I
F
D
E
D
V
P
N
S
P
N
Q
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
85.7
87.4
N.A.
74.3
76.9
N.A.
64.2
61
52.8
41.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
87.7
92.6
N.A.
84.8
85.6
N.A.
73.6
74.5
68.4
57
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
0
0
N.A.
66.6
0
N.A.
6.6
20
6.6
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
26.6
26.6
N.A.
73.3
20
N.A.
13.3
33.3
26.6
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.1
N.A.
N.A.
22.9
22.7
N.A.
Protein Similarity:
40.2
N.A.
N.A.
42.3
44.5
N.A.
P-Site Identity:
6.6
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
40
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
8
8
8
24
0
8
0
0
% A
% Cys:
0
39
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
16
0
16
0
8
0
0
8
8
8
0
0
8
% D
% Glu:
0
0
24
8
0
16
16
0
8
8
8
0
16
0
8
% E
% Phe:
0
0
0
8
0
8
0
8
8
0
8
0
16
8
8
% F
% Gly:
8
8
16
0
0
24
8
16
8
0
16
0
0
8
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
16
8
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
16
8
16
8
0
0
0
16
8
16
8
0
0
% K
% Leu:
24
0
0
8
0
8
16
0
0
8
8
8
8
31
16
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
16
8
0
0
0
8
8
8
0
8
8
8
16
0
0
% N
% Pro:
0
0
0
0
8
0
0
8
16
0
0
8
0
0
8
% P
% Gln:
0
8
8
0
16
8
31
0
8
8
0
0
0
16
0
% Q
% Arg:
0
0
0
0
24
8
8
0
0
16
0
24
8
8
0
% R
% Ser:
31
8
16
47
24
8
8
16
24
0
8
16
8
8
31
% S
% Thr:
16
0
0
8
0
8
0
24
16
8
8
8
0
8
0
% T
% Val:
0
0
0
0
0
0
0
8
8
16
0
0
16
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
24
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _