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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM4 All Species: 15.15
Human Site: S145 Identified Species: 23.81
UniProt: P33991 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33991 NP_005905.2 863 96558 S145 D I V A S E Q S L G Q K L V I
Chimpanzee Pan troglodytes XP_528129 863 96543 S145 D I V A S E Q S L G Q K L V I
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535063 929 104136 A211 D I V A S E Q A L G Q K L V I
Cat Felis silvestris
Mouse Mus musculus P49717 862 96718 L145 I V P S E Q S L G Q K L V I W
Rat Rattus norvegicus NP_387500 862 96552 L145 T V A S E Q S L G Q K L V I W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515513 863 97108 T145 D I I T S E Q T L G Q K L V I
Chicken Gallus gallus XP_424376 859 96866 R145 A E Q S L G Q R L V I W G T D
Frog Xenopus laevis P30664 863 97105 S145 E L V T S E Q S L G Q K L V I
Zebra Danio Brachydanio rerio NP_944595 750 84021 D99 T P A R Q R A D L G S V R K A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26454 866 96592 S147 T D P V S E S S Q A P Q L V V
Honey Bee Apis mellifera XP_624670 636 71159
Nematode Worm Caenorhab. elegans Q21902 759 84917 D108 E A A K I V A D E I T T P R P
Sea Urchin Strong. purpuratus XP_801985 910 101460 V187 A T E P T G A V T S D Q P G G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315 L65 S E E F L G R L T E N T R R Y
Baker's Yeast Sacchar. cerevisiae P30665 933 104985 N196 E C T T N F R N F L M S F K Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 87.6 N.A. 94.9 95.1 N.A. 92.4 86.3 85.7 71.3 N.A. 60.1 42.1 28.1 63.3
Protein Similarity: 100 100 N.A. 90 N.A. 97 97.3 N.A. 96.1 93.1 92.9 78.7 N.A. 77.3 54.3 46.9 76.3
P-Site Identity: 100 100 N.A. 93.3 N.A. 0 0 N.A. 80 13.3 80 13.3 N.A. 33.3 0 0 0
P-Site Similarity: 100 100 N.A. 100 N.A. 40 40 N.A. 93.3 20 93.3 13.3 N.A. 46.6 0 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 28.9 42.6 N.A.
Protein Similarity: N.A. N.A. N.A. 46.5 62.3 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 7 20 20 0 0 20 7 0 7 0 0 0 0 7 % A
% Cys: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 27 7 0 0 0 0 0 14 0 0 7 0 0 0 7 % D
% Glu: 20 14 14 0 14 40 0 0 7 7 0 0 0 0 0 % E
% Phe: 0 0 0 7 0 7 0 0 7 0 0 0 7 0 0 % F
% Gly: 0 0 0 0 0 20 0 0 14 40 0 0 7 7 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 27 7 0 7 0 0 0 0 7 7 0 0 14 34 % I
% Lys: 0 0 0 7 0 0 0 0 0 0 14 34 0 14 0 % K
% Leu: 0 7 0 0 14 0 0 20 47 7 0 14 40 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % M
% Asn: 0 0 0 0 7 0 0 7 0 0 7 0 0 0 0 % N
% Pro: 0 7 14 7 0 0 0 0 0 0 7 0 14 0 7 % P
% Gln: 0 0 7 0 7 14 40 0 7 14 34 14 0 0 0 % Q
% Arg: 0 0 0 7 0 7 14 7 0 0 0 0 14 14 0 % R
% Ser: 7 0 0 20 40 0 20 27 0 7 7 7 0 0 0 % S
% Thr: 20 7 7 20 7 0 0 7 14 0 7 14 0 7 0 % T
% Val: 0 14 27 7 0 7 0 7 0 7 0 7 14 40 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 14 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _