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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM5
All Species:
19.09
Human Site:
S136
Identified Species:
32.31
UniProt:
P33992
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33992
NP_006730.2
734
82286
S136
K
S
D
A
S
P
S
S
I
R
S
L
K
S
D
Chimpanzee
Pan troglodytes
XP_001156025
734
82237
S136
K
S
D
A
S
P
S
S
I
R
S
L
K
S
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_853134
634
70391
D100
L
P
R
K
C
N
T
D
Q
A
G
R
P
K
C
Cat
Felis silvestris
Mouse
Mus musculus
P49718
733
82324
S136
K
S
D
A
S
P
S
S
I
R
I
L
K
S
D
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006243
734
82391
N136
R
S
D
A
N
A
A
N
I
R
S
L
K
S
D
Frog
Xenopus laevis
P55862
735
82417
N137
R
S
D
A
N
P
A
N
I
R
S
L
K
S
E
Zebra Danio
Brachydanio rerio
NP_848523
736
81753
S137
K
S
D
A
H
P
A
S
I
R
S
L
K
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
N273
F
N
A
D
K
T
R
N
M
R
S
L
N
P
E
Honey Bee
Apis mellifera
XP_624292
732
82413
S131
S
S
D
A
H
P
S
S
L
R
G
I
K
P
D
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
S136
T
L
D
E
Y
P
T
S
L
R
Q
V
K
S
A
Sea Urchin
Strong. purpuratus
XP_801948
734
82932
A132
K
S
E
A
N
P
I
A
I
R
N
L
K
S
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9SX03
768
85190
K129
C
V
E
G
I
V
T
K
C
S
L
V
R
P
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
R139
F
K
A
P
S
K
G
R
P
S
T
I
R
E
V
Baker's Yeast
Sacchar. cerevisiae
P29496
775
86392
P147
N
S
N
A
N
Q
I
P
L
R
D
L
D
S
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
82.1
N.A.
94.8
N.A.
N.A.
N.A.
88.1
86.2
80.3
N.A.
28.6
69.8
59.9
74.9
Protein Similarity:
100
99.7
N.A.
84.3
N.A.
97.6
N.A.
N.A.
N.A.
95.6
96.1
92.2
N.A.
47.5
85.1
76.5
89.3
P-Site Identity:
100
100
N.A.
0
N.A.
93.3
N.A.
N.A.
N.A.
66.6
66.6
80
N.A.
20
60
40
60
P-Site Similarity:
100
100
N.A.
6.6
N.A.
93.3
N.A.
N.A.
N.A.
93.3
100
93.3
N.A.
46.6
73.3
60
93.3
Percent
Protein Identity:
N.A.
31.7
N.A.
31.6
47.2
N.A.
Protein Similarity:
N.A.
51.1
N.A.
50.1
62.8
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
33.3
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
26.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
15
65
0
8
22
8
0
8
0
0
0
0
8
% A
% Cys:
8
0
0
0
8
0
0
0
8
0
0
0
0
0
8
% C
% Asp:
0
0
58
8
0
0
0
8
0
0
8
0
8
0
36
% D
% Glu:
0
0
15
8
0
0
0
0
0
0
0
0
0
8
36
% E
% Phe:
15
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
8
0
0
0
15
0
0
0
0
% G
% His:
0
0
0
0
15
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
15
0
50
0
8
15
0
0
0
% I
% Lys:
36
8
0
8
8
8
0
8
0
0
0
0
65
8
8
% K
% Leu:
8
8
0
0
0
0
0
0
22
0
8
65
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
8
8
8
0
29
8
0
22
0
0
8
0
8
0
0
% N
% Pro:
0
8
0
8
0
58
0
8
8
0
0
0
8
22
0
% P
% Gln:
0
0
0
0
0
8
0
0
8
0
8
0
0
0
0
% Q
% Arg:
15
0
8
0
0
0
8
8
0
79
0
8
15
0
0
% R
% Ser:
8
65
0
0
29
0
29
43
0
15
43
0
0
65
0
% S
% Thr:
8
0
0
0
0
8
22
0
0
0
8
0
0
0
0
% T
% Val:
0
8
0
0
0
8
0
0
0
0
0
15
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _