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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM5
All Species:
17.27
Human Site:
S309
Identified Species:
29.23
UniProt:
P33992
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33992
NP_006730.2
734
82286
S309
D
T
D
G
S
G
R
S
F
A
G
A
V
S
P
Chimpanzee
Pan troglodytes
XP_001156025
734
82237
S309
D
T
D
G
S
G
R
S
F
A
G
A
V
S
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_853134
634
70391
P266
G
G
S
R
K
R
L
P
D
G
L
T
R
R
G
Cat
Felis silvestris
Mouse
Mus musculus
P49718
733
82324
S308
D
T
D
G
S
G
R
S
F
A
G
S
V
S
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006243
734
82391
S309
D
V
E
G
S
G
H
S
F
A
G
A
V
T
P
Frog
Xenopus laevis
P55862
735
82417
S310
D
T
E
G
T
G
R
S
A
A
G
A
I
T
P
Zebra Danio
Brachydanio rerio
NP_848523
736
81753
R310
V
D
T
E
G
A
G
R
G
A
T
G
S
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
K439
L
Y
E
D
E
E
G
K
D
H
I
F
P
P
E
Honey Bee
Apis mellifera
XP_624292
732
82413
G304
S
V
D
G
E
N
T
G
N
G
S
H
S
C
V
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
F310
S
G
P
G
R
T
N
F
T
T
F
T
P
E
E
Sea Urchin
Strong. purpuratus
XP_801948
734
82932
R305
V
D
Q
E
G
L
G
R
T
S
T
A
H
H
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9SX03
768
85190
N296
D
T
F
D
L
L
G
N
S
L
A
P
S
I
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
E305
T
H
F
K
K
K
Y
E
E
Y
E
F
Q
K
D
Baker's Yeast
Sacchar. cerevisiae
P29496
775
86392
E338
L
G
I
Q
S
D
V
E
T
S
S
I
W
N
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
82.1
N.A.
94.8
N.A.
N.A.
N.A.
88.1
86.2
80.3
N.A.
28.6
69.8
59.9
74.9
Protein Similarity:
100
99.7
N.A.
84.3
N.A.
97.6
N.A.
N.A.
N.A.
95.6
96.1
92.2
N.A.
47.5
85.1
76.5
89.3
P-Site Identity:
100
100
N.A.
0
N.A.
93.3
N.A.
N.A.
N.A.
73.3
66.6
6.6
N.A.
0
13.3
6.6
6.6
P-Site Similarity:
100
100
N.A.
0
N.A.
100
N.A.
N.A.
N.A.
86.6
93.3
6.6
N.A.
6.6
13.3
6.6
13.3
Percent
Protein Identity:
N.A.
31.7
N.A.
31.6
47.2
N.A.
Protein Similarity:
N.A.
51.1
N.A.
50.1
62.8
N.A.
P-Site Identity:
N.A.
13.3
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
8
43
8
36
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
43
15
29
15
0
8
0
0
15
0
0
0
0
0
8
% D
% Glu:
0
0
22
15
15
8
0
15
8
0
8
0
0
8
15
% E
% Phe:
0
0
15
0
0
0
0
8
29
0
8
15
0
0
0
% F
% Gly:
8
22
0
50
15
36
29
8
8
15
36
8
0
0
8
% G
% His:
0
8
0
0
0
0
8
0
0
8
0
8
8
8
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
8
8
8
8
8
% I
% Lys:
0
0
0
8
15
8
0
8
0
0
0
0
0
8
0
% K
% Leu:
15
0
0
0
8
15
8
0
0
8
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
8
8
8
0
0
0
0
8
0
% N
% Pro:
0
0
8
0
0
0
0
8
0
0
0
8
15
8
36
% P
% Gln:
0
0
8
8
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
8
8
8
29
15
0
0
0
0
8
8
0
% R
% Ser:
15
0
8
0
36
0
0
36
8
15
15
8
22
22
15
% S
% Thr:
8
36
8
0
8
8
8
0
22
8
15
15
0
15
0
% T
% Val:
15
15
0
0
0
0
8
0
0
0
0
0
29
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
8
0
0
0
0
8
0
0
8
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _