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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM5 All Species: 50.3
Human Site: S388 Identified Species: 85.13
UniProt: P33992 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33992 NP_006730.2 734 82286 S388 G D P G T A K S Q L L K F V E
Chimpanzee Pan troglodytes XP_001156025 734 82237 S388 G D P G T A K S Q L L K F V E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_853134 634 70391 C343 L A D G G V V C I D E F D K M
Cat Felis silvestris
Mouse Mus musculus P49718 733 82324 S387 G D P G T A K S Q L L K F V E
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006243 734 82391 S388 G D P G T A K S Q L L K F V E
Frog Xenopus laevis P55862 735 82417 S389 G D P G T A K S Q L L K F V E
Zebra Danio Brachydanio rerio NP_848523 736 81753 S390 G D P G T A K S Q L L K F V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26454 866 96592 S519 G D P G T S K S Q M L Q Y V F
Honey Bee Apis mellifera XP_624292 732 82413 S385 G D P G T A K S Q L L K F V E
Nematode Worm Caenorhab. elegans Q21902 759 84917 S387 G D P G T A K S Q L L K F V E
Sea Urchin Strong. purpuratus XP_801948 734 82932 S386 G D P G T A K S Q L L K F V E
Poplar Tree Populus trichocarpa
Maize Zea mays Q9SX03 768 85190 T374 G S S G V G L T A A V T S D Q
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315 S383 G D P G V A K S Q L L K H I I
Baker's Yeast Sacchar. cerevisiae P29496 775 86392 S423 G D P G T A K S Q L L K F V E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 N.A. 82.1 N.A. 94.8 N.A. N.A. N.A. 88.1 86.2 80.3 N.A. 28.6 69.8 59.9 74.9
Protein Similarity: 100 99.7 N.A. 84.3 N.A. 97.6 N.A. N.A. N.A. 95.6 96.1 92.2 N.A. 47.5 85.1 76.5 89.3
P-Site Identity: 100 100 N.A. 6.6 N.A. 100 N.A. N.A. N.A. 100 100 100 N.A. 66.6 100 100 100
P-Site Similarity: 100 100 N.A. 6.6 N.A. 100 N.A. N.A. N.A. 100 100 100 N.A. 93.3 100 100 100
Percent
Protein Identity: N.A. 31.7 N.A. 31.6 47.2 N.A.
Protein Similarity: N.A. 51.1 N.A. 50.1 62.8 N.A.
P-Site Identity: N.A. 13.3 N.A. 73.3 100 N.A.
P-Site Similarity: N.A. 33.3 N.A. 80 100 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 79 0 0 8 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 86 8 0 0 0 0 0 0 8 0 0 8 8 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 72 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 72 0 8 % F
% Gly: 93 0 0 100 8 8 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 0 0 8 8 % I
% Lys: 0 0 0 0 0 0 86 0 0 0 0 79 0 8 0 % K
% Leu: 8 0 0 0 0 0 8 0 0 79 86 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 86 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 86 0 0 8 0 0 8 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 8 8 0 0 8 0 86 0 0 0 0 8 0 0 % S
% Thr: 0 0 0 0 79 0 0 8 0 0 0 8 0 0 0 % T
% Val: 0 0 0 0 15 8 8 0 0 0 8 0 0 79 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _