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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM5
All Species:
34.24
Human Site:
S665
Identified Species:
57.95
UniProt:
P33992
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33992
NP_006730.2
734
82286
S665
S
G
V
E
G
F
T
S
Q
E
D
Q
E
M
L
Chimpanzee
Pan troglodytes
XP_001156025
734
82237
S665
S
G
V
E
G
F
T
S
Q
E
D
Q
E
M
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_853134
634
70391
L579
L
S
R
I
E
K
Q
L
K
R
R
F
A
I
G
Cat
Felis silvestris
Mouse
Mus musculus
P49718
733
82324
T664
S
G
V
E
G
F
T
T
Q
E
D
Q
E
M
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006243
734
82391
T665
S
G
A
E
G
F
T
T
Q
E
D
Q
E
M
L
Frog
Xenopus laevis
P55862
735
82417
T666
S
G
V
E
G
F
T
T
Q
E
D
Q
E
M
L
Zebra Danio
Brachydanio rerio
NP_848523
736
81753
T667
S
G
V
E
G
F
T
T
Q
E
D
Q
E
M
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
A795
L
T
T
G
L
S
T
A
A
R
K
K
R
A
D
Honey Bee
Apis mellifera
XP_624292
732
82413
S663
A
G
A
E
G
F
T
S
D
E
D
H
E
M
L
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
S689
A
G
V
E
G
F
T
S
T
A
D
Q
E
A
L
Sea Urchin
Strong. purpuratus
XP_801948
734
82932
T665
S
G
V
E
G
F
A
T
Q
E
D
Q
E
E
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9SX03
768
85190
E661
E
R
E
Q
R
E
M
E
M
K
Q
Q
A
D
H
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
S654
K
A
G
L
D
A
I
S
D
T
Y
S
I
I
R
Baker's Yeast
Sacchar. cerevisiae
P29496
775
86392
G705
G
G
L
N
Q
A
S
G
T
S
L
S
E
I
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
82.1
N.A.
94.8
N.A.
N.A.
N.A.
88.1
86.2
80.3
N.A.
28.6
69.8
59.9
74.9
Protein Similarity:
100
99.7
N.A.
84.3
N.A.
97.6
N.A.
N.A.
N.A.
95.6
96.1
92.2
N.A.
47.5
85.1
76.5
89.3
P-Site Identity:
100
100
N.A.
0
N.A.
93.3
N.A.
N.A.
N.A.
86.6
93.3
86.6
N.A.
6.6
73.3
73.3
80
P-Site Similarity:
100
100
N.A.
13.3
N.A.
100
N.A.
N.A.
N.A.
93.3
100
100
N.A.
20
80
80
86.6
Percent
Protein Identity:
N.A.
31.7
N.A.
31.6
47.2
N.A.
Protein Similarity:
N.A.
51.1
N.A.
50.1
62.8
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
20
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
8
15
0
0
15
8
8
8
8
0
0
15
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
15
0
65
0
0
8
8
% D
% Glu:
8
0
8
65
8
8
0
8
0
58
0
0
72
8
0
% E
% Phe:
0
0
0
0
0
65
0
0
0
0
0
8
0
0
0
% F
% Gly:
8
72
8
8
65
0
0
8
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% H
% Ile:
0
0
0
8
0
0
8
0
0
0
0
0
8
22
8
% I
% Lys:
8
0
0
0
0
8
0
0
8
8
8
8
0
0
0
% K
% Leu:
15
0
8
8
8
0
0
8
0
0
8
0
0
0
58
% L
% Met:
0
0
0
0
0
0
8
0
8
0
0
0
0
50
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
8
0
8
0
50
0
8
65
0
0
0
% Q
% Arg:
0
8
8
0
8
0
0
0
0
15
8
0
8
0
15
% R
% Ser:
50
8
0
0
0
8
8
36
0
8
0
15
0
0
0
% S
% Thr:
0
8
8
0
0
0
65
36
15
8
0
0
0
0
0
% T
% Val:
0
0
50
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _