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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM5
All Species:
18.18
Human Site:
T180
Identified Species:
30.77
UniProt:
P33992
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33992
NP_006730.2
734
82286
T180
R
S
C
R
N
T
L
T
N
I
A
M
R
P
G
Chimpanzee
Pan troglodytes
XP_001156025
734
82237
T180
R
S
C
R
N
T
L
T
N
I
A
M
R
P
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_853134
634
70391
H144
P
H
G
E
M
P
R
H
M
Q
L
Y
C
D
R
Cat
Felis silvestris
Mouse
Mus musculus
P49718
733
82324
T180
R
S
C
H
N
T
L
T
N
I
A
M
P
R
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006243
734
82391
N180
R
S
C
R
N
T
I
N
N
I
A
V
R
P
G
Frog
Xenopus laevis
P55862
735
82417
G181
R
S
C
R
N
T
I
G
N
I
A
V
R
P
G
Zebra Danio
Brachydanio rerio
NP_848523
736
81753
S181
R
G
C
R
A
V
I
S
N
I
P
L
P
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
T317
N
I
C
S
F
S
T
T
V
E
V
D
R
G
R
Honey Bee
Apis mellifera
XP_624292
732
82413
S175
R
S
C
R
S
M
Q
S
N
I
S
I
K
P
G
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
P180
R
Q
C
K
H
T
I
P
D
V
S
I
K
P
G
Sea Urchin
Strong. purpuratus
XP_801948
734
82932
P176
R
S
C
R
N
Y
M
P
N
L
T
L
K
P
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9SX03
768
85190
R173
T
G
S
V
Y
P
T
R
D
D
N
G
N
L
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
H183
Y
T
C
E
D
C
G
H
E
I
Y
Q
E
V
T
Baker's Yeast
Sacchar. cerevisiae
P29496
775
86392
S191
R
N
C
R
H
T
T
S
I
T
I
N
N
F
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
82.1
N.A.
94.8
N.A.
N.A.
N.A.
88.1
86.2
80.3
N.A.
28.6
69.8
59.9
74.9
Protein Similarity:
100
99.7
N.A.
84.3
N.A.
97.6
N.A.
N.A.
N.A.
95.6
96.1
92.2
N.A.
47.5
85.1
76.5
89.3
P-Site Identity:
100
100
N.A.
0
N.A.
73.3
N.A.
N.A.
N.A.
80
80
46.6
N.A.
20
53.3
33.3
53.3
P-Site Similarity:
100
100
N.A.
0
N.A.
73.3
N.A.
N.A.
N.A.
93.3
93.3
66.6
N.A.
26.6
86.6
86.6
80
Percent
Protein Identity:
N.A.
31.7
N.A.
31.6
47.2
N.A.
Protein Similarity:
N.A.
51.1
N.A.
50.1
62.8
N.A.
P-Site Identity:
N.A.
0
N.A.
13.3
26.6
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
26.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
0
36
0
0
0
0
% A
% Cys:
0
0
86
0
0
8
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
15
8
0
8
0
8
0
% D
% Glu:
0
0
0
15
0
0
0
0
8
8
0
0
8
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
15
8
0
0
0
8
8
0
0
0
8
0
8
58
% G
% His:
0
8
0
8
15
0
0
15
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
29
0
8
58
8
15
0
0
0
% I
% Lys:
0
0
0
8
0
0
0
0
0
0
0
0
22
0
0
% K
% Leu:
0
0
0
0
0
0
22
0
0
8
8
15
0
8
8
% L
% Met:
0
0
0
0
8
8
8
0
8
0
0
22
0
0
0
% M
% Asn:
8
8
0
0
43
0
0
8
58
0
8
8
15
0
8
% N
% Pro:
8
0
0
0
0
15
0
15
0
0
8
0
15
58
8
% P
% Gln:
0
8
0
0
0
0
8
0
0
8
0
8
0
0
0
% Q
% Arg:
72
0
0
58
0
0
8
8
0
0
0
0
36
8
15
% R
% Ser:
0
50
8
8
8
8
0
22
0
0
15
0
0
0
0
% S
% Thr:
8
8
0
0
0
50
22
29
0
8
8
0
0
0
8
% T
% Val:
0
0
0
8
0
8
0
0
8
8
8
15
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
8
8
0
0
0
0
8
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _