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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM5
All Species:
16.36
Human Site:
T277
Identified Species:
27.69
UniProt:
P33992
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33992
NP_006730.2
734
82286
T277
S
I
K
K
F
G
L
T
T
S
R
G
R
D
R
Chimpanzee
Pan troglodytes
XP_001156025
734
82237
T277
S
I
K
K
F
G
L
T
A
S
R
G
R
D
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_853134
634
70391
V234
A
L
P
N
V
Y
E
V
I
S
K
S
I
A
P
Cat
Felis silvestris
Mouse
Mus musculus
P49718
733
82324
N276
S
I
K
K
F
G
L
N
P
S
K
G
R
D
R
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006243
734
82391
S277
S
I
K
K
S
A
Q
S
K
N
K
S
R
D
N
Frog
Xenopus laevis
P55862
735
82417
T278
S
I
R
K
S
G
K
T
S
T
K
G
R
D
R
Zebra Danio
Brachydanio rerio
NP_848523
736
81753
T278
S
I
K
K
V
A
Q
T
K
A
K
G
R
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
L407
T
P
L
K
T
G
G
L
S
S
S
V
K
S
V
Honey Bee
Apis mellifera
XP_624292
732
82413
T272
S
I
K
K
V
T
K
T
T
G
N
R
G
G
K
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
K278
S
I
K
K
L
I
Q
K
K
G
G
D
K
S
L
Sea Urchin
Strong. purpuratus
XP_801948
734
82932
V273
S
I
K
K
A
G
P
V
S
K
R
T
R
K
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9SX03
768
85190
L264
I
A
N
N
V
S
L
L
N
K
E
A
N
A
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
P273
E
F
S
G
I
F
L
P
I
P
Y
T
G
F
K
Baker's Yeast
Sacchar. cerevisiae
P29496
775
86392
G306
S
I
Y
N
S
K
N
G
A
G
S
G
R
S
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
82.1
N.A.
94.8
N.A.
N.A.
N.A.
88.1
86.2
80.3
N.A.
28.6
69.8
59.9
74.9
Protein Similarity:
100
99.7
N.A.
84.3
N.A.
97.6
N.A.
N.A.
N.A.
95.6
96.1
92.2
N.A.
47.5
85.1
76.5
89.3
P-Site Identity:
100
93.3
N.A.
6.6
N.A.
80
N.A.
N.A.
N.A.
40
60
53.3
N.A.
20
40
26.6
46.6
P-Site Similarity:
100
93.3
N.A.
26.6
N.A.
86.6
N.A.
N.A.
N.A.
60
86.6
73.3
N.A.
40
46.6
33.3
53.3
Percent
Protein Identity:
N.A.
31.7
N.A.
31.6
47.2
N.A.
Protein Similarity:
N.A.
51.1
N.A.
50.1
62.8
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
26.6
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
8
15
0
0
15
8
0
8
0
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
8
0
43
0
% D
% Glu:
8
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% E
% Phe:
0
8
0
0
22
8
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
8
0
43
8
8
0
22
8
43
15
8
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
72
0
0
8
8
0
0
15
0
0
0
8
0
0
% I
% Lys:
0
0
58
72
0
8
15
8
22
15
36
0
15
8
22
% K
% Leu:
0
8
8
0
8
0
36
15
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
22
0
0
8
8
8
8
8
0
8
0
8
% N
% Pro:
0
8
8
0
0
0
8
8
8
8
0
0
0
0
15
% P
% Gln:
0
0
0
0
0
0
22
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
22
8
58
0
29
% R
% Ser:
72
0
8
0
22
8
0
8
22
36
15
15
0
22
0
% S
% Thr:
8
0
0
0
8
8
0
36
15
8
0
15
0
0
8
% T
% Val:
0
0
0
0
29
0
0
15
0
0
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
8
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _