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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM5 All Species: 17.58
Human Site: Y212 Identified Species: 29.74
UniProt: P33992 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33992 NP_006730.2 734 82286 Y212 P K C P L D P Y F I M P D K C
Chimpanzee Pan troglodytes XP_001156025 734 82237 Y212 P K C P L D P Y F I M P D K C
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_853134 634 70391 L176 Y S I K K F G L T T S K G R D
Cat Felis silvestris
Mouse Mus musculus P49718 733 82324 F212 K C P L D P Y F I M P D K C K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006243 734 82391 Y212 P R C P L D P Y F I M P D K C
Frog Xenopus laevis P55862 735 82417 Y213 P N C P L D P Y F I I P D K C
Zebra Danio Brachydanio rerio NP_848523 736 81753 Y213 V K C P V D P Y F I I P D R C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26454 866 96592 F349 L I H N R S E F T D K Q L V K
Honey Bee Apis mellifera XP_624292 732 82413 F207 P K C P L D P F F I M P D K C
Nematode Worm Caenorhab. elegans Q21902 759 84917 P212 M Q R C P I D P Y I M L P D K
Sea Urchin Strong. purpuratus XP_801948 734 82932 F208 P K C P L D P F F I V P D K C
Poplar Tree Populus trichocarpa
Maize Zea mays Q9SX03 768 85190 A205 Q E V P E N S A P G Q L P R T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315 I215 N S K A G N P I L Q L R A S K
Baker's Yeast Sacchar. cerevisiae P29496 775 86392 N223 E S E S S M A N E S N I G D E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 N.A. 82.1 N.A. 94.8 N.A. N.A. N.A. 88.1 86.2 80.3 N.A. 28.6 69.8 59.9 74.9
Protein Similarity: 100 99.7 N.A. 84.3 N.A. 97.6 N.A. N.A. N.A. 95.6 96.1 92.2 N.A. 47.5 85.1 76.5 89.3
P-Site Identity: 100 100 N.A. 0 N.A. 0 N.A. N.A. N.A. 93.3 86.6 73.3 N.A. 0 93.3 13.3 86.6
P-Site Similarity: 100 100 N.A. 6.6 N.A. 13.3 N.A. N.A. N.A. 100 93.3 93.3 N.A. 6.6 100 26.6 100
Percent
Protein Identity: N.A. 31.7 N.A. 31.6 47.2 N.A.
Protein Similarity: N.A. 51.1 N.A. 50.1 62.8 N.A.
P-Site Identity: N.A. 6.6 N.A. 6.6 0 N.A.
P-Site Similarity: N.A. 26.6 N.A. 20 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 8 8 0 0 0 0 8 0 0 % A
% Cys: 0 8 50 8 0 0 0 0 0 0 0 0 0 8 50 % C
% Asp: 0 0 0 0 8 50 8 0 0 8 0 8 50 15 8 % D
% Glu: 8 8 8 0 8 0 8 0 8 0 0 0 0 0 8 % E
% Phe: 0 0 0 0 0 8 0 29 50 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 8 0 0 8 0 0 15 0 0 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 8 0 0 8 0 8 8 58 15 8 0 0 0 % I
% Lys: 8 36 8 8 8 0 0 0 0 0 8 8 8 43 29 % K
% Leu: 8 0 0 8 43 0 0 8 8 0 8 15 8 0 0 % L
% Met: 8 0 0 0 0 8 0 0 0 8 36 0 0 0 0 % M
% Asn: 8 8 0 8 0 15 0 8 0 0 8 0 0 0 0 % N
% Pro: 43 0 8 58 8 8 58 8 8 0 8 50 15 0 0 % P
% Gln: 8 8 0 0 0 0 0 0 0 8 8 8 0 0 0 % Q
% Arg: 0 8 8 0 8 0 0 0 0 0 0 8 0 22 0 % R
% Ser: 0 22 0 8 8 8 8 0 0 8 8 0 0 8 0 % S
% Thr: 0 0 0 0 0 0 0 0 15 8 0 0 0 0 8 % T
% Val: 8 0 8 0 8 0 0 0 0 0 8 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 8 36 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _