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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM5 All Species: 38.48
Human Site: Y332 Identified Species: 65.13
UniProt: P33992 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33992 NP_006730.2 734 82286 Y332 L A A L P N V Y E V I S K S I
Chimpanzee Pan troglodytes XP_001156025 734 82237 Y332 L A A L P N V Y E V I S K S I
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_853134 634 70391 K287 L G D P G T A K S Q L L K F V
Cat Felis silvestris
Mouse Mus musculus P49718 733 82324 Y331 L A A L P N I Y E L I S K S I
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006243 734 82391 Y332 L T A M P N I Y E V V A K S I
Frog Xenopus laevis P55862 735 82417 Y333 L A A K P D I Y E T V A K S I
Zebra Danio Brachydanio rerio NP_848523 736 81753 Y334 L A A S P S V Y D S L A R S L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26454 866 96592 R463 K K P D I Y D R L A R A I A P
Honey Bee Apis mellifera XP_624292 732 82413 Y329 F A S D S N L Y E R I A R S I
Nematode Worm Caenorhab. elegans Q21902 759 84917 Y331 L A Q R K D A Y E L I A K S I
Sea Urchin Strong. purpuratus XP_801948 734 82932 Y330 L S A N P N I Y E I I A R S I
Poplar Tree Populus trichocarpa
Maize Zea mays Q9SX03 768 85190 G318 A V V L L M L G G V E K N L K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315 Y327 L A E D G D I Y N K L S R S L
Baker's Yeast Sacchar. cerevisiae P29496 775 86392 Y367 L S R N P K L Y E I L T N S I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 N.A. 82.1 N.A. 94.8 N.A. N.A. N.A. 88.1 86.2 80.3 N.A. 28.6 69.8 59.9 74.9
Protein Similarity: 100 99.7 N.A. 84.3 N.A. 97.6 N.A. N.A. N.A. 95.6 96.1 92.2 N.A. 47.5 85.1 76.5 89.3
P-Site Identity: 100 100 N.A. 13.3 N.A. 86.6 N.A. N.A. N.A. 66.6 60 46.6 N.A. 0 46.6 53.3 60
P-Site Similarity: 100 100 N.A. 26.6 N.A. 100 N.A. N.A. N.A. 93.3 86.6 86.6 N.A. 13.3 73.3 73.3 93.3
Percent
Protein Identity: N.A. 31.7 N.A. 31.6 47.2 N.A.
Protein Similarity: N.A. 51.1 N.A. 50.1 62.8 N.A.
P-Site Identity: N.A. 13.3 N.A. 33.3 40 N.A.
P-Site Similarity: N.A. 20 N.A. 66.6 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 58 50 0 0 0 15 0 0 8 0 50 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 22 0 22 8 0 8 0 0 0 0 0 0 % D
% Glu: 0 0 8 0 0 0 0 0 65 0 8 0 0 0 0 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 8 0 0 15 0 0 8 8 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 36 0 0 15 43 0 8 0 65 % I
% Lys: 8 8 0 8 8 8 0 8 0 8 0 8 50 0 8 % K
% Leu: 79 0 0 29 8 0 22 0 8 15 29 8 0 8 15 % L
% Met: 0 0 0 8 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 15 0 43 0 0 8 0 0 0 15 0 0 % N
% Pro: 0 0 8 8 58 0 0 0 0 0 0 0 0 0 8 % P
% Gln: 0 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % Q
% Arg: 0 0 8 8 0 0 0 8 0 8 8 0 29 0 0 % R
% Ser: 0 15 8 8 8 8 0 0 8 8 0 29 0 79 0 % S
% Thr: 0 8 0 0 0 8 0 0 0 8 0 8 0 0 0 % T
% Val: 0 8 8 0 0 0 22 0 0 29 15 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 79 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _