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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM5
All Species:
29.7
Human Site:
Y703
Identified Species:
50.26
UniProt:
P33992
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33992
NP_006730.2
734
82286
Y703
K
D
F
T
K
Q
K
Y
P
E
H
A
I
H
K
Chimpanzee
Pan troglodytes
XP_001156025
734
82237
Y703
K
D
F
T
K
Q
K
Y
P
E
H
A
I
H
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_853134
634
70391
R617
K
V
L
Q
L
M
L
R
R
G
E
I
Q
H
R
Cat
Felis silvestris
Mouse
Mus musculus
P49718
733
82324
Y702
Q
D
F
T
K
Q
K
Y
P
E
H
A
I
R
K
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006243
734
82391
Y703
Q
D
F
I
R
Q
K
Y
P
E
H
A
I
Y
K
Frog
Xenopus laevis
P55862
735
82417
Y704
Q
D
F
L
K
Q
K
Y
P
E
H
A
I
H
K
Zebra Danio
Brachydanio rerio
NP_848523
736
81753
Y705
Q
D
F
A
K
Q
K
Y
P
E
H
A
I
Q
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
S833
F
S
D
I
K
E
G
S
Q
I
M
I
T
R
E
Honey Bee
Apis mellifera
XP_624292
732
82413
Y701
K
D
F
V
K
Q
A
Y
P
E
R
A
I
Y
K
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
H727
Q
D
F
V
A
R
Q
H
Y
R
E
S
L
V
K
Sea Urchin
Strong. purpuratus
XP_801948
734
82932
Y703
Q
D
F
L
R
Q
K
Y
P
E
R
S
I
H
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9SX03
768
85190
V699
V
G
S
N
D
Q
N
V
S
A
E
R
I
Q
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
K692
G
Y
S
E
A
Q
L
K
E
C
L
E
E
Y
A
Baker's Yeast
Sacchar. cerevisiae
P29496
775
86392
F743
E
F
V
D
T
H
R
F
S
Q
L
A
L
D
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
82.1
N.A.
94.8
N.A.
N.A.
N.A.
88.1
86.2
80.3
N.A.
28.6
69.8
59.9
74.9
Protein Similarity:
100
99.7
N.A.
84.3
N.A.
97.6
N.A.
N.A.
N.A.
95.6
96.1
92.2
N.A.
47.5
85.1
76.5
89.3
P-Site Identity:
100
100
N.A.
13.3
N.A.
86.6
N.A.
N.A.
N.A.
73.3
86.6
80
N.A.
6.6
73.3
20
66.6
P-Site Similarity:
100
100
N.A.
20
N.A.
93.3
N.A.
N.A.
N.A.
93.3
93.3
86.6
N.A.
20
80
60
86.6
Percent
Protein Identity:
N.A.
31.7
N.A.
31.6
47.2
N.A.
Protein Similarity:
N.A.
51.1
N.A.
50.1
62.8
N.A.
P-Site Identity:
N.A.
13.3
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
15
0
8
0
0
8
0
58
0
0
15
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
65
8
8
8
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
8
0
0
8
0
8
0
0
8
58
22
8
8
0
8
% E
% Phe:
8
8
65
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
8
8
0
0
0
0
8
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
0
8
0
0
43
0
0
36
0
% H
% Ile:
0
0
0
15
0
0
0
0
0
8
0
15
65
0
0
% I
% Lys:
29
0
0
0
50
0
50
8
0
0
0
0
0
0
72
% K
% Leu:
0
0
8
15
8
0
15
0
0
0
15
0
15
0
0
% L
% Met:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
58
0
0
0
0
0
0
% P
% Gln:
43
0
0
8
0
72
8
0
8
8
0
0
8
15
0
% Q
% Arg:
0
0
0
0
15
8
8
8
8
8
15
8
0
15
8
% R
% Ser:
0
8
15
0
0
0
0
8
15
0
0
15
0
0
0
% S
% Thr:
0
0
0
22
8
0
0
0
0
0
0
0
8
0
0
% T
% Val:
8
8
8
15
0
0
0
8
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
58
8
0
0
0
0
22
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _