Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM7 All Species: 57.27
Human Site: T405 Identified Species: 84
UniProt: P33993 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33993 NP_005907.3 719 81308 T405 A P R S Q Y T T G R G S S G V
Chimpanzee Pan troglodytes XP_527834 716 80774 T405 A P R S Q Y T T G R G S S G V
Rhesus Macaque Macaca mulatta XP_001101053 719 81187 T405 A P R S Q Y T T G R G S S G V
Dog Lupus familis XP_849809 719 81456 T405 A P R S Q Y T T G R G S S G V
Cat Felis silvestris
Mouse Mus musculus Q61881 719 81192 T405 A P R S Q Y T T G R G S S G V
Rat Rattus norvegicus NP_001004203 719 81044 T405 A P R S Q Y T T G R G S S G V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZMN2 812 91233 K414 V C I D E F D K M S D I D R T
Frog Xenopus laevis Q91876 720 81860 T404 A P R S Q Y T T G R G S S G V
Zebra Danio Brachydanio rerio NP_997734 721 80978 T405 A P R S Q Y T T G R G S S G V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26454 866 96592 S536 V P R S Q Y T S G R G S S A V
Honey Bee Apis mellifera XP_393469 725 82814 T410 A P R S Q Y T T G R G S S G V
Nematode Worm Caenorhab. elegans NP_504199 730 81599 T414 A P R S Q Y T T G R G S S G V
Sea Urchin Strong. purpuratus XP_780248 712 80030 T396 A P R S Q Y T T G R G S S G V
Poplar Tree Populus trichocarpa
Maize Zea mays Q9SX03 768 85190 K408 V C I D E F D K M N D Q D R V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315 T400 A P R G V Y T T G K G S S G V
Baker's Yeast Sacchar. cerevisiae P38132 845 94857 T484 S P R G V Y T T G K G S S G V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.1 98.4 96.2 N.A. 92.7 94.3 N.A. N.A. 32.6 83.7 80.5 N.A. 31.1 63.1 49.1 70.7
Protein Similarity: 100 96.6 99.3 98.1 N.A. 97.6 98.3 N.A. N.A. 50.2 92.9 90 N.A. 48.6 77.6 68.9 84.7
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 0 100 100 N.A. 80 100 100 100
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 13.3 100 100 N.A. 86.6 100 100 100
Percent
Protein Identity: N.A. 32 N.A. 50.3 42.2 N.A.
Protein Similarity: N.A. 52.8 N.A. 67 58.9 N.A.
P-Site Identity: N.A. 6.6 N.A. 80 73.3 N.A.
P-Site Similarity: N.A. 20 N.A. 86.6 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 75 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % A
% Cys: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 13 0 0 13 0 0 0 13 0 13 0 0 % D
% Glu: 0 0 0 0 13 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 13 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 13 0 0 0 0 88 0 88 0 0 82 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 13 0 0 0 0 0 0 0 0 7 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 13 0 13 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % N
% Pro: 0 88 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 75 0 0 0 0 0 0 7 0 0 0 % Q
% Arg: 0 0 88 0 0 0 0 0 0 75 0 0 0 13 0 % R
% Ser: 7 0 0 75 0 0 0 7 0 7 0 88 88 0 0 % S
% Thr: 0 0 0 0 0 0 88 82 0 0 0 0 0 0 7 % T
% Val: 19 0 0 0 13 0 0 0 0 0 0 0 0 0 94 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 88 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _