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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM7 All Species: 36.06
Human Site: Y126 Identified Species: 52.89
UniProt: P33993 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33993 NP_005907.3 719 81308 Y126 V R S P Q N Q Y P A E L M R R
Chimpanzee Pan troglodytes XP_527834 716 80774 Y126 V R S P Q N Q Y P A E L M R R
Rhesus Macaque Macaca mulatta XP_001101053 719 81187 Y126 A R S P Q N Q Y P A E L M R R
Dog Lupus familis XP_849809 719 81456 Y126 A R S P Q N Q Y P P E L M R R
Cat Felis silvestris
Mouse Mus musculus Q61881 719 81192 Y126 V R N P Q N Q Y P S E L M R R
Rat Rattus norvegicus NP_001004203 719 81044 Y126 V R N P Q N Q Y P S E L M R R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZMN2 812 91233 G130 S C I V C V E G I V T K C S L
Frog Xenopus laevis Q91876 720 81860 Y125 M R D S Q N Q Y P P E L M R R
Zebra Danio Brachydanio rerio NP_997734 721 80978 Y126 T R D H R K Q Y P P E L M R R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26454 866 96592 R251 I N E M F F E R Y P A A L L E
Honey Bee Apis mellifera XP_393469 725 82814 Y130 Q R D P R N K Y A P E L M R R
Nematode Worm Caenorhab. elegans NP_504199 730 81599 Y139 L Q D K R K K Y P P Q L L Q R
Sea Urchin Strong. purpuratus XP_780248 712 80030 L127 E L M R R Y E L Y F K I P S Q
Poplar Tree Populus trichocarpa
Maize Zea mays Q9SX03 768 85190 S140 V R P K V V K S V H F C P V T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315 K125 Q Q I P S E I K R Y Y E V Y F
Baker's Yeast Sacchar. cerevisiae P38132 845 94857 F204 T R R Y F L Y F K P L S Q N C
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.1 98.4 96.2 N.A. 92.7 94.3 N.A. N.A. 32.6 83.7 80.5 N.A. 31.1 63.1 49.1 70.7
Protein Similarity: 100 96.6 99.3 98.1 N.A. 97.6 98.3 N.A. N.A. 50.2 92.9 90 N.A. 48.6 77.6 68.9 84.7
P-Site Identity: 100 100 93.3 86.6 N.A. 86.6 86.6 N.A. N.A. 0 73.3 60 N.A. 0 60 26.6 0
P-Site Similarity: 100 100 93.3 86.6 N.A. 100 100 N.A. N.A. 6.6 80 66.6 N.A. 20 73.3 73.3 33.3
Percent
Protein Identity: N.A. 32 N.A. 50.3 42.2 N.A.
Protein Similarity: N.A. 52.8 N.A. 67 58.9 N.A.
P-Site Identity: N.A. 13.3 N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. 20 N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 0 0 0 0 0 0 0 7 19 7 7 0 0 0 % A
% Cys: 0 7 0 0 7 0 0 0 0 0 0 7 7 0 7 % C
% Asp: 0 0 25 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 7 0 7 0 0 7 19 0 0 0 57 7 0 0 7 % E
% Phe: 0 0 0 0 13 7 0 7 0 7 7 0 0 0 7 % F
% Gly: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % G
% His: 0 0 0 7 0 0 0 0 0 7 0 0 0 0 0 % H
% Ile: 7 0 13 0 0 0 7 0 7 0 0 7 0 0 0 % I
% Lys: 0 0 0 13 0 13 19 7 7 0 7 7 0 0 0 % K
% Leu: 7 7 0 0 0 7 0 7 0 0 7 63 13 7 7 % L
% Met: 7 0 7 7 0 0 0 0 0 0 0 0 57 0 0 % M
% Asn: 0 7 13 0 0 50 0 0 0 0 0 0 0 7 0 % N
% Pro: 0 0 7 50 0 0 0 0 57 44 0 0 13 0 0 % P
% Gln: 13 13 0 0 44 0 50 0 0 0 7 0 7 7 7 % Q
% Arg: 0 69 7 7 25 0 0 7 7 0 0 0 0 57 63 % R
% Ser: 7 0 25 7 7 0 0 7 0 13 0 7 0 13 0 % S
% Thr: 13 0 0 0 0 0 0 0 0 0 7 0 0 0 7 % T
% Val: 32 0 0 7 7 13 0 0 7 7 0 0 7 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 7 7 63 13 7 7 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _