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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SHMT1
All Species:
20.91
Human Site:
Y104
Identified Species:
35.38
UniProt:
P34896
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34896
NP_004160.3
483
53083
Y104
Q
K
R
A
L
Q
A
Y
K
L
D
P
Q
C
W
Chimpanzee
Pan troglodytes
XP_511325
483
53092
Y104
Q
K
R
A
L
Q
A
Y
K
L
D
P
Q
C
W
Rhesus Macaque
Macaca mulatta
XP_001096193
483
53122
Y104
Q
K
R
A
L
Q
A
Y
K
L
D
P
Q
C
W
Dog
Lupus familis
XP_851819
483
53313
E108
Q
V
Y
G
L
D
P
E
C
W
G
V
N
V
Q
Cat
Felis silvestris
Mouse
Mus musculus
P50431
478
52566
C104
A
Y
H
L
D
P
Q
C
W
G
V
N
V
Q
P
Rat
Rattus norvegicus
NP_001041307
681
75356
Y301
Q
K
R
A
L
Q
A
Y
H
L
D
P
Q
C
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510083
484
53208
Y104
Q
K
R
A
L
Q
A
Y
N
L
D
P
Q
S
W
Chicken
Gallus gallus
XP_414824
580
63427
F201
Q
K
R
A
L
Q
A
F
R
L
D
P
Q
K
W
Frog
Xenopus laevis
NP_001080356
485
53733
Y105
Q
K
R
A
L
E
V
Y
G
L
E
P
Q
K
W
Zebra Danio
Brachydanio rerio
NP_957340
481
53365
D104
A
L
K
V
Y
G
L
D
P
E
K
W
G
V
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P50432
507
55746
F130
Q
K
R
A
L
E
V
F
G
L
D
P
A
K
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SZJ5
517
57382
F133
Q
K
R
A
L
E
A
F
R
L
D
P
E
K
W
Baker's Yeast
Sacchar. cerevisiae
P37291
469
52200
V104
V
T
P
D
K
W
G
V
N
V
Q
T
L
S
G
Red Bread Mold
Neurospora crassa
P34898
480
52959
G104
H
L
D
P
K
Q
W
G
V
N
V
Q
C
L
S
Conservation
Percent
Protein Identity:
100
99.7
98.1
91.3
N.A.
90.2
65
N.A.
87.5
67.9
78.9
78.8
N.A.
N.A.
N.A.
57.9
N.A.
Protein Similarity:
100
99.7
98.5
96
N.A.
94.1
68.1
N.A.
94
75.3
87.2
88.8
N.A.
N.A.
N.A.
73.1
N.A.
P-Site Identity:
100
100
100
13.3
N.A.
0
93.3
N.A.
86.6
80
66.6
0
N.A.
N.A.
N.A.
60
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
0
93.3
N.A.
86.6
93.3
80
6.6
N.A.
N.A.
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
54.7
53.6
56.9
Protein Similarity:
N.A.
N.A.
N.A.
70.6
72.4
73
P-Site Identity:
N.A.
N.A.
N.A.
66.6
0
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
93.3
6.6
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
65
0
0
50
0
0
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
8
0
0
0
8
29
0
% C
% Asp:
0
0
8
8
8
8
0
8
0
0
58
0
0
0
0
% D
% Glu:
0
0
0
0
0
22
0
8
0
8
8
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
22
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
8
8
8
15
8
8
0
8
0
8
% G
% His:
8
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
65
8
0
15
0
0
0
22
0
8
0
0
29
0
% K
% Leu:
0
15
0
8
72
0
8
0
0
65
0
0
8
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
15
8
0
8
8
0
8
% N
% Pro:
0
0
8
8
0
8
8
0
8
0
0
65
0
0
8
% P
% Gln:
72
0
0
0
0
50
8
0
0
0
8
8
50
8
8
% Q
% Arg:
0
0
65
0
0
0
0
0
15
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
8
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% T
% Val:
8
8
0
8
0
0
15
8
8
8
15
8
8
15
0
% V
% Trp:
0
0
0
0
0
8
8
0
8
8
0
8
0
0
65
% W
% Tyr:
0
8
8
0
8
0
0
43
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _