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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EPHX2
All Species:
12.12
Human Site:
S374
Identified Species:
26.67
UniProt:
P34913
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34913
NP_001970.2
555
62616
S374
P
N
M
S
P
L
E
S
I
K
A
N
P
V
F
Chimpanzee
Pan troglodytes
XP_001163779
555
62479
S374
P
N
V
S
P
L
E
S
I
K
A
N
P
V
F
Rhesus Macaque
Macaca mulatta
XP_001109474
556
62466
S375
P
N
V
P
P
L
E
S
I
K
A
N
P
V
F
Dog
Lupus familis
XP_534566
556
61919
K374
P
N
V
S
T
M
E
K
I
K
A
N
P
V
F
Cat
Felis silvestris
Mouse
Mus musculus
P34914
554
62497
V372
P
D
V
S
P
M
K
V
I
R
S
I
P
V
F
Rat
Rattus norvegicus
P80299
554
62322
V372
P
E
V
S
P
M
E
V
I
R
S
I
P
V
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521600
530
58804
L349
L
S
R
T
L
K
L
L
I
R
A
S
D
E
K
Chicken
Gallus gallus
NP_001028817
562
63232
T374
P
T
V
D
I
V
E
T
M
K
S
F
P
M
F
Frog
Xenopus laevis
NP_001087143
560
62571
R375
P
G
V
N
A
L
E
R
I
K
A
N
P
I
F
Zebra Danio
Brachydanio rerio
NP_001008642
557
61874
K370
P
N
T
N
P
M
E
K
L
M
A
I
P
I
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001121538
562
63381
N375
D
T
M
N
P
W
E
N
I
N
K
N
P
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
93.5
78.4
N.A.
73.1
72.9
N.A.
55.3
55.5
55.8
49.1
N.A.
N.A.
N.A.
N.A.
44.3
Protein Similarity:
100
99.8
96.9
89.3
N.A.
86.6
86.6
N.A.
69
74.5
73
67.6
N.A.
N.A.
N.A.
N.A.
63.3
P-Site Identity:
100
93.3
86.6
73.3
N.A.
46.6
53.3
N.A.
13.3
33.3
60
46.6
N.A.
N.A.
N.A.
N.A.
40
P-Site Similarity:
100
100
93.3
86.6
N.A.
86.6
80
N.A.
40
73.3
80
73.3
N.A.
N.A.
N.A.
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
0
0
0
64
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
10
0
0
0
0
0
0
0
0
10
0
0
% D
% Glu:
0
10
0
0
0
0
82
0
0
0
0
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
82
% F
% Gly:
0
10
0
0
0
0
0
0
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
0
82
0
0
28
0
19
0
% I
% Lys:
0
0
0
0
0
10
10
19
0
55
10
0
0
0
10
% K
% Leu:
10
0
0
0
10
37
10
10
10
0
0
0
0
0
10
% L
% Met:
0
0
19
0
0
37
0
0
10
10
0
0
0
10
0
% M
% Asn:
0
46
0
28
0
0
0
10
0
10
0
55
0
0
0
% N
% Pro:
82
0
0
10
64
0
0
0
0
0
0
0
91
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
10
0
0
0
0
10
0
28
0
0
0
0
0
% R
% Ser:
0
10
0
46
0
0
0
28
0
0
28
10
0
0
0
% S
% Thr:
0
19
10
10
10
0
0
10
0
0
0
0
0
0
0
% T
% Val:
0
0
64
0
0
10
0
19
0
0
0
0
0
55
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _