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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EPHX2
All Species:
14.55
Human Site:
S418
Identified Species:
32
UniProt:
P34913
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34913
NP_001970.2
555
62616
S418
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
Chimpanzee
Pan troglodytes
XP_001163779
555
62479
S418
A
S
D
E
S
V
L
S
M
H
K
V
C
E
A
Rhesus Macaque
Macaca mulatta
XP_001109474
556
62466
S419
A
S
D
E
S
V
L
S
M
H
K
V
C
E
M
Dog
Lupus familis
XP_534566
556
61919
N419
S
D
G
K
P
F
L
N
V
G
R
V
R
E
R
Cat
Felis silvestris
Mouse
Mus musculus
P34914
554
62497
A417
S
D
E
T
G
F
I
A
V
H
K
A
T
E
I
Rat
Rattus norvegicus
P80299
554
62322
T417
S
D
D
M
G
L
L
T
V
N
K
A
T
E
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521600
530
58804
F394
Q
Q
F
E
K
S
G
F
R
G
P
L
N
W
Y
Chicken
Gallus gallus
NP_001028817
562
63232
G423
D
R
L
H
S
V
P
G
L
L
G
V
Q
E
R
Frog
Xenopus laevis
NP_001087143
560
62571
T424
D
R
L
P
T
T
L
T
T
M
N
V
R
E
R
Zebra Danio
Brachydanio rerio
NP_001008642
557
61874
S418
T
G
G
F
P
K
L
S
P
A
G
V
C
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001121538
562
63381
F422
L
E
L
K
E
I
G
F
S
V
A
G
V
R
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
93.5
78.4
N.A.
73.1
72.9
N.A.
55.3
55.5
55.8
49.1
N.A.
N.A.
N.A.
N.A.
44.3
Protein Similarity:
100
99.8
96.9
89.3
N.A.
86.6
86.6
N.A.
69
74.5
73
67.6
N.A.
N.A.
N.A.
N.A.
63.3
P-Site Identity:
100
100
93.3
20
N.A.
20
26.6
N.A.
6.6
26.6
20
26.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
93.3
53.3
N.A.
53.3
60
N.A.
13.3
33.3
33.3
33.3
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
28
0
0
0
0
0
0
10
0
10
10
19
0
0
28
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
37
0
0
% C
% Asp:
19
28
37
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
10
10
37
10
0
0
0
0
0
0
0
0
73
0
% E
% Phe:
0
0
10
10
0
19
0
19
0
0
0
0
0
0
0
% F
% Gly:
0
10
19
0
19
0
19
10
0
19
19
10
0
0
0
% G
% His:
0
0
0
10
0
0
0
0
0
37
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
10
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
0
19
10
10
0
0
0
0
46
0
0
0
0
% K
% Leu:
10
0
28
0
0
10
64
0
10
10
0
10
0
0
0
% L
% Met:
0
0
0
10
0
0
0
0
28
10
0
0
0
0
19
% M
% Asn:
0
0
0
0
0
0
0
10
0
10
10
0
10
0
0
% N
% Pro:
0
0
0
10
19
0
10
0
10
0
10
0
0
0
0
% P
% Gln:
10
10
0
0
0
0
0
0
0
0
0
0
10
10
0
% Q
% Arg:
0
19
0
0
0
0
0
0
10
0
10
0
19
10
37
% R
% Ser:
28
28
0
0
37
10
0
37
10
0
0
0
0
0
0
% S
% Thr:
10
0
0
10
10
10
0
19
10
0
0
0
19
0
0
% T
% Val:
0
0
0
0
0
37
0
0
28
10
0
64
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _