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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSPA4
All Species:
44.55
Human Site:
S278
Identified Species:
75.38
UniProt:
P34932
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34932
NP_002145.3
840
94331
S278
E
K
L
K
K
L
M
S
A
N
A
S
D
L
P
Chimpanzee
Pan troglodytes
XP_517930
840
94350
S278
E
K
L
K
K
L
M
S
A
N
A
S
D
L
P
Rhesus Macaque
Macaca mulatta
XP_001106968
840
94362
S278
E
K
L
K
K
L
M
S
A
N
A
S
D
L
P
Dog
Lupus familis
XP_533297
840
94621
S278
E
K
L
K
K
L
M
S
A
N
A
S
D
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61316
841
94114
S278
E
K
L
K
K
L
M
S
A
N
A
S
D
L
P
Rat
Rattus norvegicus
O88600
840
94038
S278
E
K
L
K
K
L
M
S
A
N
A
S
D
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510127
834
93982
S272
E
K
L
K
K
L
M
S
A
N
A
S
D
L
P
Chicken
Gallus gallus
XP_414655
840
94222
S278
E
K
L
K
K
L
M
S
A
N
A
S
D
L
P
Frog
Xenopus laevis
P02827
647
70897
A162
Q
R
Q
A
T
K
D
A
G
V
L
A
G
L
N
Zebra Danio
Brachydanio rerio
NP_956151
840
94728
S278
E
K
L
K
K
L
M
S
A
N
S
S
D
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q05036
776
86878
S280
E
R
V
K
K
Q
M
S
A
N
Q
T
P
I
P
Sea Urchin
Strong. purpuratus
Q06068
889
98600
S278
D
K
T
K
K
L
M
S
A
N
A
T
L
I
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32590
693
77602
S207
G
L
V
D
I
G
H
S
T
Y
T
C
S
I
M
Red Bread Mold
Neurospora crassa
O74225
707
78655
K222
K
K
G
E
L
S
V
K
S
T
A
C
D
R
H
Conservation
Percent
Protein Identity:
100
99.7
99.5
63.9
N.A.
95.8
95.8
N.A.
87
85.9
27.8
73.2
N.A.
N.A.
N.A.
42
50.2
Protein Similarity:
100
99.7
99.7
79.6
N.A.
97.8
98.2
N.A.
92.3
93.2
46.1
85.8
N.A.
N.A.
N.A.
59.1
67.2
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
6.6
93.3
N.A.
N.A.
N.A.
53.3
60
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
33.3
100
N.A.
N.A.
N.A.
80
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
34.5
38.4
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
51.5
55
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
8
79
0
72
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% C
% Asp:
8
0
0
8
0
0
8
0
0
0
0
0
72
0
0
% D
% Glu:
72
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
8
0
0
8
0
0
8
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
0
8
0
0
0
0
0
0
0
0
22
0
% I
% Lys:
8
79
0
79
79
8
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
8
65
0
8
72
0
0
0
0
8
0
8
72
0
% L
% Met:
0
0
0
0
0
0
79
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
79
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
72
% P
% Gln:
8
0
8
0
0
8
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
15
0
0
0
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
0
0
0
8
0
86
8
0
8
65
8
0
8
% S
% Thr:
0
0
8
0
8
0
0
0
8
8
8
15
0
0
0
% T
% Val:
0
0
15
0
0
0
8
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _