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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSPA4
All Species:
26.97
Human Site:
Y597
Identified Species:
45.64
UniProt:
P34932
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34932
NP_002145.3
840
94331
Y597
D
R
E
M
L
N
L
Y
I
E
N
E
G
K
M
Chimpanzee
Pan troglodytes
XP_517930
840
94350
Y597
D
R
E
M
L
N
L
Y
I
E
N
E
G
K
M
Rhesus Macaque
Macaca mulatta
XP_001106968
840
94362
Y597
D
R
E
M
L
N
L
Y
I
E
N
E
G
K
M
Dog
Lupus familis
XP_533297
840
94621
Y601
G
Q
D
L
L
N
S
Y
I
E
N
E
G
K
M
Cat
Felis silvestris
Mouse
Mus musculus
Q61316
841
94114
Y598
D
R
E
M
L
A
L
Y
T
E
N
E
G
K
M
Rat
Rattus norvegicus
O88600
840
94038
Y597
D
R
E
M
L
G
L
Y
T
E
N
E
G
K
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510127
834
93982
Y591
G
R
D
M
L
N
L
Y
I
E
N
E
G
K
M
Chicken
Gallus gallus
XP_414655
840
94222
F597
G
K
D
M
L
N
L
F
I
E
N
E
G
K
M
Frog
Xenopus laevis
P02827
647
70897
D453
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
Zebra Danio
Brachydanio rerio
NP_956151
840
94728
F599
A
N
D
M
L
N
L
F
V
E
S
E
G
K
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q05036
776
86878
S579
A
K
A
D
A
K
N
S
L
E
E
Y
V
Y
E
Sea Urchin
Strong. purpuratus
Q06068
889
98600
F632
S
I
T
E
V
N
N
F
F
E
K
E
G
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32590
693
77602
T498
I
I
E
N
A
Y
T
T
E
D
I
T
V
Q
E
Red Bread Mold
Neurospora crassa
O74225
707
78655
N513
E
E
E
V
K
D
E
N
G
D
V
V
M
E
G
Conservation
Percent
Protein Identity:
100
99.7
99.5
63.9
N.A.
95.8
95.8
N.A.
87
85.9
27.8
73.2
N.A.
N.A.
N.A.
42
50.2
Protein Similarity:
100
99.7
99.7
79.6
N.A.
97.8
98.2
N.A.
92.3
93.2
46.1
85.8
N.A.
N.A.
N.A.
59.1
67.2
P-Site Identity:
100
100
100
66.6
N.A.
86.6
86.6
N.A.
86.6
73.3
13.3
60
N.A.
N.A.
N.A.
6.6
33.3
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
93.3
93.3
20
86.6
N.A.
N.A.
N.A.
20
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
34.5
38.4
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
51.5
55
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
8
8
15
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
36
0
29
8
0
8
0
8
0
15
0
0
0
0
0
% D
% Glu:
8
15
50
8
0
0
8
0
8
79
8
72
0
8
15
% E
% Phe:
0
0
0
0
0
0
0
22
8
0
0
0
0
0
8
% F
% Gly:
29
0
0
0
0
8
0
0
8
0
0
0
79
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
15
0
0
0
0
0
0
43
0
8
0
0
0
0
% I
% Lys:
0
15
0
0
8
8
8
0
0
0
8
0
0
79
0
% K
% Leu:
0
0
0
8
65
0
58
0
8
0
8
8
0
0
8
% L
% Met:
0
0
0
58
8
0
0
0
0
0
0
0
8
0
65
% M
% Asn:
0
8
0
8
0
58
15
8
8
8
58
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
43
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
0
8
8
0
0
8
0
0
0
0
% S
% Thr:
0
0
8
0
0
8
8
8
15
0
0
8
0
0
0
% T
% Val:
0
0
0
8
8
0
0
0
8
0
8
8
15
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
50
0
0
0
8
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _