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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MPI All Species: 7.88
Human Site: S318 Identified Species: 14.44
UniProt: P34949 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P34949 NP_002426.1 423 46656 S318 M L S Y T P S S S K D R L F L
Chimpanzee Pan troglodytes A5A6K3 423 46593 S318 M L S Y T P S S S K D R L F L
Rhesus Macaque Macaca mulatta XP_001098369 246 27237 G150 T P F Q G L C G F R P V E E I
Dog Lupus familis XP_535543 421 46205 P316 C E M L S Y T P S K D R L F L
Cat Felis silvestris
Mouse Mus musculus Q924M7 423 46556 P318 M L N Y T P S P S N N R L F A
Rat Rattus norvegicus Q68FX1 423 46405 P318 M L D Y T P S P S K D R L F A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511999 423 46243 P318 M L N Y T P A P S S A K L F T
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623842 403 45248 P304 M L S Y I C E P I S A K R F Q
Nematode Worm Caenorhab. elegans P34650 416 46365 L301 M L N Y D E T L L P K Y I P N
Sea Urchin Strong. purpuratus XP_780304 431 46368 T323 M L T Y L P S T P D E K I F P
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001140476 435 47737 F330 M L T Y K Q A F P E I L R G V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P29952 429 48170 P323 M L T Y T Y D P V E K Q K M Q
Red Bread Mold Neurospora crassa Q870Y1 459 50345 P331 M L T Y D F A P I E Q Q K M E
Conservation
Percent
Protein Identity: 100 99.5 55.7 88.4 N.A. 84.6 85.5 N.A. 73.2 N.A. N.A. N.A. N.A. N.A. 44.4 39.7 48.7
Protein Similarity: 100 99.7 56.9 93.3 N.A. 91.2 91 N.A. 81.8 N.A. N.A. N.A. N.A. N.A. 61.7 58.3 66.3
P-Site Identity: 100 100 0 46.6 N.A. 66.6 80 N.A. 53.3 N.A. N.A. N.A. N.A. N.A. 33.3 20 40
P-Site Similarity: 100 100 13.3 60 N.A. 80 80 N.A. 73.3 N.A. N.A. N.A. N.A. N.A. 40 40 73.3
Percent
Protein Identity: N.A. 40.9 N.A. N.A. 40.7 38.1
Protein Similarity: N.A. 55.8 N.A. N.A. 59.9 54.6
P-Site Identity: N.A. 20 N.A. N.A. 26.6 20
P-Site Similarity: N.A. 46.6 N.A. N.A. 46.6 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 24 0 0 0 16 0 0 0 16 % A
% Cys: 8 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 16 0 8 0 0 8 31 0 0 0 0 % D
% Glu: 0 8 0 0 0 8 8 0 0 24 8 0 8 8 8 % E
% Phe: 0 0 8 0 0 8 0 8 8 0 0 0 0 62 0 % F
% Gly: 0 0 0 0 8 0 0 8 0 0 0 0 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 16 0 8 0 16 0 8 % I
% Lys: 0 0 0 0 8 0 0 0 0 31 16 24 16 0 0 % K
% Leu: 0 85 0 8 8 8 0 8 8 0 0 8 47 0 24 % L
% Met: 85 0 8 0 0 0 0 0 0 0 0 0 0 16 0 % M
% Asn: 0 0 24 0 0 0 0 0 0 8 8 0 0 0 8 % N
% Pro: 0 8 0 0 0 47 0 54 16 8 8 0 0 8 8 % P
% Gln: 0 0 0 8 0 8 0 0 0 0 8 16 0 0 16 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 0 39 16 0 0 % R
% Ser: 0 0 24 0 8 0 39 16 47 16 0 0 0 0 0 % S
% Thr: 8 0 31 0 47 0 16 8 0 0 0 0 0 0 8 % T
% Val: 0 0 0 0 0 0 0 0 8 0 0 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 85 0 16 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _