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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MPI All Species: 16.36
Human Site: T376 Identified Species: 30
UniProt: P34949 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P34949 NP_002426.1 423 46656 T376 I L L M V Q G T V I A S T P T
Chimpanzee Pan troglodytes A5A6K3 423 46593 T376 I L L M V Q G T V I A S T P T
Rhesus Macaque Macaca mulatta XP_001098369 246 27237 V208 L M K S E K K V V A E Q L N L
Dog Lupus familis XP_535543 421 46205 R374 I L L V V Q G R V T A S T P T
Cat Felis silvestris
Mouse Mus musculus Q924M7 423 46556 T376 I L L M V Q G T V T A I I P S
Rat Rattus norvegicus Q68FX1 423 46405 T376 I L L L V Q G T V T A I I P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511999 423 46243 E376 I L L V V Q G E A T G P S T A
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623842 403 45248 E362 I I I N G K G E I S P S K I L
Nematode Worm Caenorhab. elegans P34650 416 46365 T359 L Y G T A T V T L G D A S Q V
Sea Urchin Strong. purpuratus XP_780304 431 46368 Q381 I I I V I E G Q G E A A H P S
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001140476 435 47737 Q388 M T G A G E I Q L D S A S D G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P29952 429 48170 T381 G P S I L I T T K G N G Y I K
Red Bread Mold Neurospora crassa Q870Y1 459 50345 S389 S L L K S Q G S K V T F K P I
Conservation
Percent
Protein Identity: 100 99.5 55.7 88.4 N.A. 84.6 85.5 N.A. 73.2 N.A. N.A. N.A. N.A. N.A. 44.4 39.7 48.7
Protein Similarity: 100 99.7 56.9 93.3 N.A. 91.2 91 N.A. 81.8 N.A. N.A. N.A. N.A. N.A. 61.7 58.3 66.3
P-Site Identity: 100 100 6.6 80 N.A. 73.3 66.6 N.A. 40 N.A. N.A. N.A. N.A. N.A. 20 6.6 26.6
P-Site Similarity: 100 100 26.6 86.6 N.A. 80 80 N.A. 53.3 N.A. N.A. N.A. N.A. N.A. 46.6 33.3 73.3
Percent
Protein Identity: N.A. 40.9 N.A. N.A. 40.7 38.1
Protein Similarity: N.A. 55.8 N.A. N.A. 59.9 54.6
P-Site Identity: N.A. 0 N.A. N.A. 6.6 33.3
P-Site Similarity: N.A. 40 N.A. N.A. 20 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 8 0 0 0 8 8 47 24 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 8 8 0 0 8 0 % D
% Glu: 0 0 0 0 8 16 0 16 0 8 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 8 0 16 0 16 0 70 0 8 16 8 8 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 62 16 16 8 8 8 8 0 8 16 0 16 16 16 8 % I
% Lys: 0 0 8 8 0 16 8 0 16 0 0 0 16 0 8 % K
% Leu: 16 54 54 8 8 0 0 0 16 0 0 0 8 0 16 % L
% Met: 8 8 0 24 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 0 0 8 0 0 8 0 % N
% Pro: 0 8 0 0 0 0 0 0 0 0 8 8 0 54 0 % P
% Gln: 0 0 0 0 0 54 0 16 0 0 0 8 0 8 0 % Q
% Arg: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % R
% Ser: 8 0 8 8 8 0 0 8 0 8 8 31 24 0 24 % S
% Thr: 0 8 0 8 0 8 8 47 0 31 8 0 24 8 24 % T
% Val: 0 0 0 24 47 0 8 8 47 8 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _