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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MPI All Species: 19.7
Human Site: T409 Identified Species: 36.11
UniProt: P34949 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P34949 NP_002426.1 423 46656 T409 E S V S L K L T E P K D L L I
Chimpanzee Pan troglodytes A5A6K3 423 46593 T409 E S V S L K L T E P K D L L I
Rhesus Macaque Macaca mulatta XP_001098369 246 27237 G239 W V Q C S D L G S P A D T R L
Dog Lupus familis XP_535543 421 46205 A407 E R V S L K L A V P S D L L L
Cat Felis silvestris
Mouse Mus musculus Q924M7 423 46556 T409 E S V L L K I T V P K D L L I
Rat Rattus norvegicus Q68FX1 423 46405 T409 E T V L L K L T V P K N L L I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511999 423 46243 T409 E S V S L Q L T S S G S L L M
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623842 403 45248 M396 C G C H P M L M F Q A F V N V
Nematode Worm Caenorhab. elegans P34650 416 46365 F398 D F L A F R A F T P S P R A L
Sea Urchin Strong. purpuratus XP_780304 431 46368 S416 E S L A F K L S P A N G L L A
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001140476 435 47737 Y425 G P E S L Q L Y R A G V N S R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P29952 429 48170 E415 L P V D L E A E D E A F T T Y
Red Bread Mold Neurospora crassa Q870Y1 459 50345 E439 A E C V L E S E D D K F E T F
Conservation
Percent
Protein Identity: 100 99.5 55.7 88.4 N.A. 84.6 85.5 N.A. 73.2 N.A. N.A. N.A. N.A. N.A. 44.4 39.7 48.7
Protein Similarity: 100 99.7 56.9 93.3 N.A. 91.2 91 N.A. 81.8 N.A. N.A. N.A. N.A. N.A. 61.7 58.3 66.3
P-Site Identity: 100 100 20 66.6 N.A. 80 73.3 N.A. 60 N.A. N.A. N.A. N.A. N.A. 6.6 6.6 40
P-Site Similarity: 100 100 26.6 73.3 N.A. 86.6 86.6 N.A. 73.3 N.A. N.A. N.A. N.A. N.A. 20 40 60
Percent
Protein Identity: N.A. 40.9 N.A. N.A. 40.7 38.1
Protein Similarity: N.A. 55.8 N.A. N.A. 59.9 54.6
P-Site Identity: N.A. 20 N.A. N.A. 13.3 13.3
P-Site Similarity: N.A. 26.6 N.A. N.A. 26.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 16 0 0 16 8 0 16 24 0 0 8 8 % A
% Cys: 8 0 16 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 8 0 8 0 0 16 8 0 39 0 0 0 % D
% Glu: 54 8 8 0 0 16 0 16 16 8 0 0 8 0 0 % E
% Phe: 0 8 0 0 16 0 0 8 8 0 0 24 0 0 8 % F
% Gly: 8 8 0 0 0 0 0 8 0 0 16 8 0 0 0 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 31 % I
% Lys: 0 0 0 0 0 47 0 0 0 0 39 0 0 0 0 % K
% Leu: 8 0 16 16 70 0 70 0 0 0 0 0 54 54 24 % L
% Met: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 8 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 8 8 8 0 % N
% Pro: 0 16 0 0 8 0 0 0 8 54 0 8 0 0 0 % P
% Gln: 0 0 8 0 0 16 0 0 0 8 0 0 0 0 0 % Q
% Arg: 0 8 0 0 0 8 0 0 8 0 0 0 8 8 8 % R
% Ser: 0 39 0 39 8 0 8 8 16 8 16 8 0 8 0 % S
% Thr: 0 8 0 0 0 0 0 39 8 0 0 0 16 16 0 % T
% Val: 0 8 54 8 0 0 0 0 24 0 0 8 8 0 8 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _