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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TRHR
All Species:
30.61
Human Site:
S178
Identified Species:
56.11
UniProt:
P34981
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34981
NP_003292.1
398
45085
S178
Y
K
D
A
I
V
I
S
C
G
Y
K
I
S
R
Chimpanzee
Pan troglodytes
XP_528214
398
45052
S178
Y
K
D
A
I
V
I
S
C
G
Y
K
I
S
R
Rhesus Macaque
Macaca mulatta
XP_001091307
398
45052
S178
Y
K
D
A
I
V
I
S
C
G
Y
K
I
S
R
Dog
Lupus familis
XP_539128
398
45121
S178
Y
K
D
A
I
V
V
S
C
G
Y
K
I
S
R
Cat
Felis silvestris
Mouse
Mus musculus
P21761
393
44541
S178
Y
K
N
A
V
V
V
S
C
G
Y
K
I
S
R
Rat
Rattus norvegicus
Q01717
412
46590
S178
Y
K
D
A
I
V
I
S
C
G
Y
K
I
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516760
263
29638
V50
N
I
M
V
V
L
V
V
M
R
T
K
H
M
R
Chicken
Gallus gallus
O93603
395
44679
S180
Y
K
D
T
T
V
V
S
C
G
Y
K
V
S
R
Frog
Xenopus laevis
O42574
385
43291
F168
G
I
S
A
L
V
S
F
L
P
I
M
M
H
W
Zebra Danio
Brachydanio rerio
NP_001108160
399
44922
T175
Y
K
D
A
T
I
I
T
C
A
Y
K
V
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8ITC7
477
53986
I222
Y
P
L
D
H
S
R
I
E
E
S
A
F
C
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_491990
395
43984
K177
L
F
L
A
T
L
I
K
D
D
I
G
T
S
C
Sea Urchin
Strong. purpuratus
XP_783972
427
47637
G208
Y
A
G
G
H
A
F
G
R
C
W
Y
R
M
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.2
97.4
N.A.
93.2
91.2
N.A.
58
81.4
27.3
64.9
N.A.
24.3
N.A.
35.4
40.9
Protein Similarity:
100
100
99.7
98.9
N.A.
96.7
93.9
N.A.
62.3
89.1
48.2
78.6
N.A.
42.3
N.A.
59.7
58.5
P-Site Identity:
100
100
100
93.3
N.A.
80
100
N.A.
13.3
73.3
13.3
66.6
N.A.
6.6
N.A.
20
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
33.3
86.6
26.6
86.6
N.A.
6.6
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
70
0
8
0
0
0
8
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
62
8
0
0
0
8
8
% C
% Asp:
0
0
54
8
0
0
0
0
8
8
0
0
0
0
8
% D
% Glu:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
8
8
0
0
0
0
8
0
0
% F
% Gly:
8
0
8
8
0
0
0
8
0
54
0
8
0
0
0
% G
% His:
0
0
0
0
16
0
0
0
0
0
0
0
8
8
0
% H
% Ile:
0
16
0
0
39
8
47
8
0
0
16
0
47
0
0
% I
% Lys:
0
62
0
0
0
0
0
8
0
0
0
70
0
0
0
% K
% Leu:
8
0
16
0
8
16
0
0
8
0
0
0
0
0
0
% L
% Met:
0
0
8
0
0
0
0
0
8
0
0
8
8
16
0
% M
% Asn:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
8
8
0
0
8
0
70
% R
% Ser:
0
0
8
0
0
8
8
54
0
0
8
0
0
70
8
% S
% Thr:
0
0
0
8
24
0
0
8
0
0
8
0
8
0
0
% T
% Val:
0
0
0
8
16
62
31
8
0
0
0
0
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% W
% Tyr:
77
0
0
0
0
0
0
0
0
0
62
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _