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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TRHR
All Species:
30.3
Human Site:
S260
Identified Species:
55.56
UniProt:
P34981
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P34981
NP_003292.1
398
45085
S260
C
F
N
S
T
V
S
S
R
K
Q
V
T
K
M
Chimpanzee
Pan troglodytes
XP_528214
398
45052
S260
C
F
N
S
T
V
S
S
R
K
Q
V
T
K
M
Rhesus Macaque
Macaca mulatta
XP_001091307
398
45052
S260
C
F
N
S
T
V
S
S
R
K
Q
V
T
K
M
Dog
Lupus familis
XP_539128
398
45121
S260
C
F
N
S
T
V
S
S
R
K
Q
V
T
K
M
Cat
Felis silvestris
Mouse
Mus musculus
P21761
393
44541
S260
C
F
N
S
T
V
S
S
R
K
Q
V
T
K
M
Rat
Rattus norvegicus
Q01717
412
46590
S260
C
F
N
S
T
V
S
S
R
K
Q
V
T
K
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516760
263
29638
K132
I
A
I
C
H
P
I
K
A
Q
F
L
C
T
F
Chicken
Gallus gallus
O93603
395
44679
S262
S
F
N
S
T
I
A
S
R
R
Q
V
T
K
M
Frog
Xenopus laevis
O42574
385
43291
S250
F
S
H
S
H
V
L
S
H
G
R
S
S
R
R
Zebra Danio
Brachydanio rerio
NP_001108160
399
44922
R257
S
T
T
A
A
S
R
R
Q
V
T
K
M
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8ITC7
477
53986
V304
I
R
M
L
A
A
V
V
I
T
F
F
V
C
W
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_491990
395
43984
Y259
S
S
T
S
M
G
H
Y
S
G
R
D
S
H
I
Sea Urchin
Strong. purpuratus
XP_783972
427
47637
G290
K
S
S
E
G
S
D
G
S
N
S
P
R
R
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.2
97.4
N.A.
93.2
91.2
N.A.
58
81.4
27.3
64.9
N.A.
24.3
N.A.
35.4
40.9
Protein Similarity:
100
100
99.7
98.9
N.A.
96.7
93.9
N.A.
62.3
89.1
48.2
78.6
N.A.
42.3
N.A.
59.7
58.5
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
73.3
20
0
N.A.
0
N.A.
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
93.3
46.6
13.3
N.A.
0
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
16
8
8
0
8
0
0
0
0
0
8
% A
% Cys:
47
0
0
8
0
0
0
0
0
0
0
0
8
8
8
% C
% Asp:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% D
% Glu:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
8
54
0
0
0
0
0
0
0
0
16
8
0
0
8
% F
% Gly:
0
0
0
0
8
8
0
8
0
16
0
0
0
0
0
% G
% His:
0
0
8
0
16
0
8
0
8
0
0
0
0
8
0
% H
% Ile:
16
0
8
0
0
8
8
0
8
0
0
0
0
0
8
% I
% Lys:
8
0
0
0
0
0
0
8
0
47
0
8
0
54
0
% K
% Leu:
0
0
0
8
0
0
8
0
0
0
0
8
0
8
0
% L
% Met:
0
0
8
0
8
0
0
0
0
0
0
0
8
0
54
% M
% Asn:
0
0
54
0
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
8
54
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
8
8
54
8
16
0
8
16
8
% R
% Ser:
24
24
8
70
0
16
47
62
16
0
8
8
16
0
0
% S
% Thr:
0
8
16
0
54
0
0
0
0
8
8
0
54
8
0
% T
% Val:
0
0
0
0
0
54
8
8
0
8
0
54
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _