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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: BTC All Species: 6.97
Human Site: S8 Identified Species: 21.9
UniProt: P35070 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35070 NP_001720.1 178 19746 S8 M D R A A R C S G A S S L P L
Chimpanzee Pan troglodytes XP_517223 178 19706 S8 M D R A A R G S G A S S L P L
Rhesus Macaque Macaca mulatta P55244 121 13164
Dog Lupus familis XP_539798 190 21395 A11 L Y L H L A I A I A I A I R W
Cat Felis silvestris
Mouse Mus musculus Q05928 177 19646 S8 M D P T A P G S S V S S L P L
Rat Rattus norvegicus P01134 159 16942 L8 M V P A A G Q L A L L A L G I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510889 431 46044 A146 S E K A A A V A T E E A E M A
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038229 178 20321 I8 M D R T R R F I F A I I S A V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.7 24.7 72.6 N.A. 79.2 31.4 N.A. 29.4 N.A. N.A. 37 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 98.3 37.6 81.5 N.A. 85.3 44.9 N.A. 34.7 N.A. N.A. 59.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 0 6.6 N.A. 60 26.6 N.A. 13.3 N.A. N.A. 33.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 93.3 0 33.3 N.A. 60 40 N.A. 40 N.A. N.A. 40 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 50 63 25 0 25 13 50 0 38 0 13 13 % A
% Cys: 0 0 0 0 0 0 13 0 0 0 0 0 0 0 0 % C
% Asp: 0 50 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 13 0 0 0 0 0 0 0 13 13 0 13 0 0 % E
% Phe: 0 0 0 0 0 0 13 0 13 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 13 25 0 25 0 0 0 0 13 0 % G
% His: 0 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 13 13 13 0 25 13 13 0 13 % I
% Lys: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 13 0 13 0 13 0 0 13 0 13 13 0 50 0 38 % L
% Met: 63 0 0 0 0 0 0 0 0 0 0 0 0 13 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 25 0 0 13 0 0 0 0 0 0 0 38 0 % P
% Gln: 0 0 0 0 0 0 13 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 38 0 13 38 0 0 0 0 0 0 0 13 0 % R
% Ser: 13 0 0 0 0 0 0 38 13 0 38 38 13 0 0 % S
% Thr: 0 0 0 25 0 0 0 0 13 0 0 0 0 0 0 % T
% Val: 0 13 0 0 0 0 13 0 0 13 0 0 0 0 13 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % W
% Tyr: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _