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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PFN2 All Species: 35.15
Human Site: T61 Identified Species: 70.3
UniProt: P35080 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35080 NP_002619.1 140 15046 T61 K D R E G F F T N G L T L G A
Chimpanzee Pan troglodytes XP_516998 125 13542 T61 K D R E G F F T N G L T L G A
Rhesus Macaque Macaca mulatta XP_001102817 303 32122 T224 K D R E G F F T N G L T L G A
Dog Lupus familis XP_849132 168 17690 V89 K D R S S F F V N G L T L G G
Cat Felis silvestris
Mouse Mus musculus Q9JJV2 140 15014 T61 K D R E G F F T N G L T L G A
Rat Rattus norvegicus Q9EPC6 140 14984 T61 K D R E G F F T N G L T L G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507138 140 15036 T61 K D R E G F F T N G L T L G A
Chicken Gallus gallus NP_001073228 140 15028 T61 K D R E G F F T N G L T L G A
Frog Xenopus laevis NP_001080782 140 15141 T61 K D R E G F F T G G L T V G G
Zebra Danio Brachydanio rerio NP_958874 139 14967 T60 K D R E G F F T S G L T L G K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays P35083 131 14219 P62 D E P G F L A P I G L F L G P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42449 131 14248 P62 E E P G F L A P T G L F L G G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 89.2 37.9 42.2 N.A. 99.2 96.4 N.A. 95.7 98.5 80 81.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 89.2 40.9 52.3 N.A. 100 97.8 N.A. 97.1 100 87.8 87.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 73.3 N.A. 100 93.3 N.A. 100 100 80 86.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 73.3 N.A. 100 93.3 N.A. 100 100 86.6 93.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. 33.5 N.A. 34.2 N.A. N.A.
Protein Similarity: N.A. 45.7 N.A. 44.2 N.A. N.A.
P-Site Identity: N.A. 26.6 N.A. 26.6 N.A. N.A.
P-Site Similarity: N.A. 33.3 N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 17 0 0 0 0 0 0 0 50 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 84 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 9 17 0 75 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 17 84 84 0 0 0 0 17 0 0 0 % F
% Gly: 0 0 0 17 75 0 0 0 9 100 0 0 0 100 34 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % I
% Lys: 84 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % K
% Leu: 0 0 0 0 0 17 0 0 0 0 100 0 92 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 67 0 0 0 0 0 0 % N
% Pro: 0 0 17 0 0 0 0 17 0 0 0 0 0 0 9 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 84 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 9 9 0 0 0 9 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 75 9 0 0 84 0 0 0 % T
% Val: 0 0 0 0 0 0 0 9 0 0 0 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _