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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PHB All Species: 31.82
Human Site: S265 Identified Species: 58.33
UniProt: P35232 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35232 NP_002625.1 272 29804 S265 T Y L P A G Q S V L L Q L P Q
Chimpanzee Pan troglodytes XP_001172437 252 27986 S245 T Y L P A G Q S V L L Q L P Q
Rhesus Macaque Macaca mulatta XP_001093129 266 29073 S259 T Y L P A G Q S V L L Q L P Q
Dog Lupus familis XP_541546 272 29846 S265 T Y L P A G Q S V L L Q L P Q
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus P67779 272 29802 S265 T Y L P A G Q S V L L Q L P Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P84173 272 29878 S265 T Y L P S G Q S V L L Q L P Q
Frog Xenopus laevis NP_001079819 272 29802 S265 T Y L P S G Q S T L L Q L P Q
Zebra Danio Brachydanio rerio NP_958454 271 29666 G264 T Y L P S G Q G T L L Q L P Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P24156 276 30365 S265 A Y L P S G Q S T L L N L P S
Honey Bee Apis mellifera XP_391959 271 29992 N264 A Y L P P G Q N V L L N L P Q
Nematode Worm Caenorhab. elegans Q9BKU4 275 29970 Q268 T Y L P G N Q Q T L L N L Q S
Sea Urchin Strong. purpuratus XP_001178147 273 30088 Q266 S Y L P Q G Q Q T L L S L P Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40961 287 31408 S267 V Y L P S Q H S G G G N S E S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.4 97.7 93.3 N.A. N.A. 99.6 N.A. N.A. 96.3 91.9 91.9 N.A. 74.2 73.9 65.4 73.6
Protein Similarity: 100 90.4 97.7 94.8 N.A. N.A. 100 N.A. N.A. 98.5 97 96.6 N.A. 86.5 86.7 81.8 89
P-Site Identity: 100 100 100 100 N.A. N.A. 100 N.A. N.A. 93.3 86.6 80 N.A. 66.6 73.3 53.3 66.6
P-Site Similarity: 100 100 100 100 N.A. N.A. 100 N.A. N.A. 100 93.3 86.6 N.A. 73.3 80 53.3 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 51.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 74.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 0 0 39 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 8 85 0 8 8 8 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 100 0 0 0 0 0 0 93 93 0 93 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 8 0 0 0 31 0 0 0 % N
% Pro: 0 0 0 100 8 0 0 0 0 0 0 0 0 85 0 % P
% Gln: 0 0 0 0 8 8 93 16 0 0 0 62 0 8 77 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 0 0 0 39 0 0 70 0 0 0 8 8 0 24 % S
% Thr: 70 0 0 0 0 0 0 0 39 0 0 0 0 0 0 % T
% Val: 8 0 0 0 0 0 0 0 54 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _