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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RFC4 All Species: 8.48
Human Site: T17 Identified Species: 14.36
UniProt: P35249 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.46
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35249 NP_002907.1 363 39682 T17 I S T K P P L T K D R G V A A
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535837 363 39624 K17 V S T K P P L K D R G I A A T
Cat Felis silvestris
Mouse Mus musculus Q99J62 364 39848 T17 V S A K A Q L T K D R G T P A
Rat Rattus norvegicus NP_001099339 364 39938 T17 V S T K P Q L T K E R G I S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513440 259 28454
Chicken Gallus gallus NP_001006550 359 39305 A18 I S S K P P A A K E R S A A G
Frog Xenopus laevis NP_001082757 363 39992 K17 S I G T K P V K D K A S A S G
Zebra Danio Brachydanio rerio NP_999902 358 39865 K17 S Q S V K A Q K P S S S S S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_573245 353 39536 K17 S T A G S G D K S Q G T P A A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P53016 334 37687 W17 K R P K V L T W T E K Y R P K
Sea Urchin Strong. purpuratus XP_787339 355 39574 S17 F K S K A A A S S T G G S T K
Poplar Tree Populus trichocarpa XP_002307456 342 38023 K21 K Y R P K Q I K D V A H Q D E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_564148 339 37489 K21 K Y R P K Q V K D V A H Q E E
Baker's Yeast Sacchar. cerevisiae P40348 353 39723 A17 K R K I S K L A A E Q S L A Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 95.3 N.A. 90.9 91.2 N.A. 61.7 83.1 80.4 74 N.A. 53.7 N.A. 39.1 61.4
Protein Similarity: 100 N.A. N.A. 98 N.A. 95.3 96.4 N.A. 67.4 90.9 90.9 87 N.A. 69.6 N.A. 58.9 76.5
P-Site Identity: 100 N.A. N.A. 46.6 N.A. 60 60 N.A. 0 53.3 6.6 0 N.A. 13.3 N.A. 6.6 13.3
P-Site Similarity: 100 N.A. N.A. 53.3 N.A. 66.6 93.3 N.A. 0 66.6 20 20 N.A. 20 N.A. 20 26.6
Percent
Protein Identity: 51.2 N.A. N.A. 52 50.1 N.A.
Protein Similarity: 68.3 N.A. N.A. 69.7 67.7 N.A.
P-Site Identity: 0 N.A. N.A. 0 13.3 N.A.
P-Site Similarity: 6.6 N.A. N.A. 6.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 15 0 15 15 15 15 8 0 22 0 22 36 22 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 8 0 29 15 0 0 0 8 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 29 0 0 0 8 15 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 8 8 0 8 0 0 0 0 22 29 0 0 15 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % H
% Ile: 15 8 0 8 0 0 8 0 0 0 0 8 8 0 0 % I
% Lys: 29 8 8 50 29 8 0 43 29 8 8 0 0 0 15 % K
% Leu: 0 0 0 0 0 8 36 0 0 0 0 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 8 15 29 29 0 0 8 0 0 0 8 15 0 % P
% Gln: 0 8 0 0 0 29 8 0 0 8 8 0 15 0 8 % Q
% Arg: 0 15 15 0 0 0 0 0 0 8 29 0 8 0 0 % R
% Ser: 22 36 22 0 15 0 0 8 15 8 8 29 15 22 15 % S
% Thr: 0 8 22 8 0 0 8 22 8 8 0 8 8 8 8 % T
% Val: 22 0 0 8 8 0 15 0 0 15 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % W
% Tyr: 0 15 0 0 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _