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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTGS2
All Species:
31.52
Human Site:
Y261
Identified Species:
77.04
UniProt:
P35354
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35354
NP_000954.1
604
68996
Y261
D
T
Q
A
E
M
I
Y
P
P
Q
V
P
E
H
Chimpanzee
Pan troglodytes
XP_524999
740
83657
Y397
D
T
Q
A
E
M
I
Y
P
P
Q
V
P
E
H
Rhesus Macaque
Macaca mulatta
XP_001107538
855
96199
Y512
D
T
Q
A
E
M
I
Y
P
P
Q
V
P
E
H
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q05769
604
68995
Y261
D
T
Q
V
E
M
I
Y
P
P
H
I
P
E
N
Rat
Rattus norvegicus
P35355
604
69146
Y261
D
T
Q
V
D
M
I
Y
P
P
H
V
P
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516281
618
70689
Y275
D
T
Q
A
E
M
I
Y
P
P
H
I
P
E
H
Chicken
Gallus gallus
P27607
603
69094
Y261
D
T
Q
A
E
M
I
Y
P
P
H
V
P
E
H
Frog
Xenopus laevis
NP_001086946
604
69026
Y262
S
S
G
V
D
M
A
Y
P
P
H
V
P
E
H
Zebra Danio
Brachydanio rerio
NP_001020675
606
69447
Y263
E
V
Q
V
D
M
H
Y
P
P
H
V
P
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VEG6
809
90521
E451
D
K
K
A
C
P
S
E
E
A
G
K
S
C
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.3
69.1
N.A.
N.A.
86.7
86.4
N.A.
83
81.6
74
73.4
N.A.
20.3
N.A.
N.A.
N.A.
Protein Similarity:
100
81.3
69.3
N.A.
N.A.
93.2
93
N.A.
90.6
90.7
87.4
85.6
N.A.
34.8
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
73.3
80
N.A.
86.6
93.3
53.3
53.3
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
86.6
86.6
N.A.
93.3
93.3
66.6
66.6
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
60
0
0
10
0
0
10
0
0
0
0
0
% A
% Cys:
0
0
0
0
10
0
0
0
0
0
0
0
0
10
0
% C
% Asp:
80
0
0
0
30
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
10
0
0
0
60
0
0
10
10
0
0
0
0
90
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% F
% Gly:
0
0
10
0
0
0
0
0
0
0
10
0
0
0
0
% G
% His:
0
0
0
0
0
0
10
0
0
0
60
0
0
0
70
% H
% Ile:
0
0
0
0
0
0
70
0
0
0
0
20
0
0
0
% I
% Lys:
0
10
10
0
0
0
0
0
0
0
0
10
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
90
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% N
% Pro:
0
0
0
0
0
10
0
0
90
90
0
0
90
0
0
% P
% Gln:
0
0
80
0
0
0
0
0
0
0
30
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
10
0
0
0
0
10
0
0
0
0
0
10
0
10
% S
% Thr:
0
70
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
10
0
40
0
0
0
0
0
0
0
70
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
90
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _