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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HRH1 All Species: 8.48
Human Site: T333 Identified Species: 14.36
UniProt: P35367 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35367 NP_000852.1 487 55784 T333 R S H G Q L K T D E Q G L N T
Chimpanzee Pan troglodytes Q9N2B2 487 55605 T333 Q S H G Q L K T D E Q G L N T
Rhesus Macaque Macaca mulatta P56490 532 60122 D357 Q T E K H D S D T P N Y F L S
Dog Lupus familis XP_541769 536 61594 M382 Q S Q S M L E M D E Q G L N M
Cat Felis silvestris
Mouse Mus musculus P70174 488 55663 E334 L S Q P K M D E Q S L S T C R
Rat Rattus norvegicus P31390 486 55674 E332 L S Q P K M D E Q S L N T C R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505379 489 54959 E335 K R D Q P S Q E N L A P A T L
Chicken Gallus gallus P30372 466 51547 K324 H L K V E N S K L T C I R I V
Frog Xenopus laevis P30544 484 54107 K341 N T A S K W S K I K I V T K Q
Zebra Danio Brachydanio rerio NP_001036196 534 61056 S380 P Q T F I N V S D C N V L V P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8IS44 506 56459 E373 F V R Y G V Q E A M T L A R N
Honey Bee Apis mellifera XP_395477 546 60788 T389 L A G L V A Q T G A L P V F S
Nematode Worm Caenorhab. elegans Q18775 517 58629 R347 S Q R N F R G R N V T I G S N
Sea Urchin Strong. purpuratus NP_001012721 677 76342 Y495 E P L R R N S Y D E R K T T S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 27 78.5 N.A. 78 78.8 N.A. 60.1 27.3 27.7 41.3 N.A. 28.6 28.3 26.8 29.2
Protein Similarity: 100 99.1 44.7 83.4 N.A. 84.6 85.6 N.A. 70.7 47.2 44.5 57.1 N.A. 48.8 43 46.8 49
P-Site Identity: 100 93.3 0 53.3 N.A. 6.6 6.6 N.A. 0 0 0 13.3 N.A. 0 6.6 0 13.3
P-Site Similarity: 100 100 20 66.6 N.A. 20 20 N.A. 20 6.6 20 20 N.A. 13.3 33.3 13.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 0 8 0 0 8 8 8 0 15 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 8 0 0 15 0 % C
% Asp: 0 0 8 0 0 8 15 8 36 0 0 0 0 0 0 % D
% Glu: 8 0 8 0 8 0 8 29 0 29 0 0 0 0 0 % E
% Phe: 8 0 0 8 8 0 0 0 0 0 0 0 8 8 0 % F
% Gly: 0 0 8 15 8 0 8 0 8 0 0 22 8 0 0 % G
% His: 8 0 15 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 8 0 8 15 0 8 0 % I
% Lys: 8 0 8 8 22 0 15 15 0 8 0 8 0 8 0 % K
% Leu: 22 8 8 8 0 22 0 0 8 8 22 8 29 8 8 % L
% Met: 0 0 0 0 8 15 0 8 0 8 0 0 0 0 8 % M
% Asn: 8 0 0 8 0 22 0 0 15 0 15 8 0 22 15 % N
% Pro: 8 8 0 15 8 0 0 0 0 8 0 15 0 0 8 % P
% Gln: 22 15 22 8 15 0 22 0 15 0 22 0 0 0 8 % Q
% Arg: 8 8 15 8 8 8 0 8 0 0 8 0 8 8 15 % R
% Ser: 8 36 0 15 0 8 29 8 0 15 0 8 0 8 22 % S
% Thr: 0 15 8 0 0 0 0 22 8 8 15 0 29 15 15 % T
% Val: 0 8 0 8 8 8 8 0 0 8 0 15 8 8 8 % V
% Trp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 8 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _