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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APLNR
All Species:
8.18
Human Site:
S335
Identified Species:
20
UniProt:
P35414
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35414
NP_005152.1
380
42660
S335
Q
S
R
C
A
G
T
S
H
S
S
S
G
E
K
Chimpanzee
Pan troglodytes
Q9GLN9
359
41015
K318
K
Y
F
L
Q
L
L
K
Y
I
P
P
K
A
K
Rhesus Macaque
Macaca mulatta
O97666
380
42588
S335
Q
S
R
C
A
G
T
S
H
S
S
S
G
E
K
Dog
Lupus familis
XP_540616
380
42193
S335
R
S
R
C
G
A
A
S
H
S
S
S
G
E
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9WV08
377
42247
P333
Q
S
G
C
K
G
T
P
H
S
S
S
A
E
K
Rat
Rattus norvegicus
Q9JHG3
377
42331
P333
Q
S
G
C
K
G
S
P
H
S
S
S
A
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517046
378
41963
A335
G
H
S
G
C
W
G
A
P
S
G
A
G
E
K
Chicken
Gallus gallus
P79785
359
41202
K318
K
Y
F
L
Q
L
I
K
Y
I
P
P
N
V
S
Frog
Xenopus laevis
P79960
362
40839
R320
L
Y
A
F
F
D
L
R
F
R
S
Q
C
F
F
Zebra Danio
Brachydanio rerio
Q7SZP9
362
40631
F321
Y
A
F
F
D
L
R
F
R
S
Q
C
L
C
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.3
98.9
93.4
N.A.
91.8
89.7
N.A.
82.3
31.5
45.2
46.8
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
51.3
99.4
95.5
N.A.
95
93.4
N.A.
87.1
50
66
63.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
100
73.3
N.A.
73.3
66.6
N.A.
26.6
0
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
100
80
N.A.
73.3
73.3
N.A.
40
13.3
6.6
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
0
20
10
10
10
0
0
0
10
20
10
0
% A
% Cys:
0
0
0
50
10
0
0
0
0
0
0
10
10
10
0
% C
% Asp:
0
0
0
0
10
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
60
0
% E
% Phe:
0
0
30
20
10
0
0
10
10
0
0
0
0
10
10
% F
% Gly:
10
0
20
10
10
40
10
0
0
0
10
0
40
0
0
% G
% His:
0
10
0
0
0
0
0
0
50
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
10
0
0
20
0
0
0
0
0
% I
% Lys:
20
0
0
0
20
0
0
20
0
0
0
0
10
0
70
% K
% Leu:
10
0
0
20
0
30
20
0
0
0
0
0
10
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
20
10
0
20
20
0
0
0
% P
% Gln:
40
0
0
0
20
0
0
0
0
0
10
10
0
0
0
% Q
% Arg:
10
0
30
0
0
0
10
10
10
10
0
0
0
0
0
% R
% Ser:
0
50
10
0
0
0
10
30
0
70
60
50
0
0
10
% S
% Thr:
0
0
0
0
0
0
30
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
30
0
0
0
0
0
0
20
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _