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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SCN1A
All Species:
21.82
Human Site:
Y545
Identified Species:
48
UniProt:
P35498
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35498
NP_008851.3
2009
228972
Y545
I
E
G
N
R
L
T
Y
E
K
R
Y
S
S
P
Chimpanzee
Pan troglodytes
XP_515872
2009
228955
Y545
I
E
G
N
R
L
T
Y
E
K
R
Y
S
S
P
Rhesus Macaque
Macaca mulatta
XP_001101023
2008
228805
Y545
I
E
G
N
R
L
T
Y
E
K
R
Y
S
S
P
Dog
Lupus familis
XP_535941
2009
228773
Y545
I
E
G
N
R
L
T
Y
E
K
R
Y
S
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q62205
1984
225794
R524
V
E
G
H
H
R
A
R
E
K
R
L
S
T
P
Rat
Rattus norvegicus
P04774
2009
228752
Y545
I
E
G
N
R
L
T
Y
E
K
R
Y
S
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512686
2008
228349
R540
S
I
R
K
K
G
F
R
F
S
I
E
G
N
R
Chicken
Gallus gallus
XP_001233839
2002
227119
R544
S
I
R
R
K
G
F
R
L
S
I
E
G
N
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q2XVR3
1829
207718
S496
L
I
V
N
R
V
S
S
N
K
E
L
S
A
E
Tiger Blowfish
Takifugu rubipres
Q2XVR7
1892
213080
S532
K
E
E
S
S
V
H
S
V
L
H
L
D
E
P
Fruit Fly
Dros. melanogaster
P35500
2131
239344
G589
R
G
R
F
G
I
P
G
S
D
R
K
P
L
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
99.6
98.5
N.A.
76.5
98.1
N.A.
88.2
90.6
N.A.
62.3
60.7
44
N.A.
N.A.
N.A.
Protein Similarity:
100
99.9
99.8
99.4
N.A.
85.9
99.3
N.A.
93.7
94.9
N.A.
74.3
73.6
61.3
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
46.6
100
N.A.
0
0
N.A.
26.6
13.3
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
66.6
100
N.A.
13.3
13.3
N.A.
53.3
26.6
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
10
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% D
% Glu:
0
64
10
0
0
0
0
0
55
0
10
19
0
10
10
% E
% Phe:
0
0
0
10
0
0
19
0
10
0
0
0
0
0
0
% F
% Gly:
0
10
55
0
10
19
0
10
0
0
0
0
19
0
0
% G
% His:
0
0
0
10
10
0
10
0
0
0
10
0
0
0
0
% H
% Ile:
46
28
0
0
0
10
0
0
0
0
19
0
0
0
0
% I
% Lys:
10
0
0
10
19
0
0
0
0
64
0
10
0
0
0
% K
% Leu:
10
0
0
0
0
46
0
0
10
10
0
28
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
55
0
0
0
0
10
0
0
0
0
19
0
% N
% Pro:
0
0
0
0
0
0
10
0
0
0
0
0
10
0
64
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
28
10
55
10
0
28
0
0
64
0
0
0
19
% R
% Ser:
19
0
0
10
10
0
10
19
10
19
0
0
64
46
0
% S
% Thr:
0
0
0
0
0
0
46
0
0
0
0
0
0
10
0
% T
% Val:
10
0
10
0
0
19
0
0
10
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
46
0
0
0
46
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _