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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLCN1 All Species: 10.3
Human Site: S723 Identified Species: 18.89
UniProt: P35523 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35523 NP_000074.2 988 108756 S723 D E D L S G K S E L P P S L A
Chimpanzee Pan troglodytes XP_527935 988 108838 S723 D E D L S G K S E L P P S L P
Rhesus Macaque Macaca mulatta XP_001092282 736 80740 G494 L S P E E P N G P L P G H K Q
Dog Lupus familis XP_859634 871 95882 L627 R S Q V V A L L G A Q L S P A
Cat Felis silvestris
Mouse Mus musculus Q64347 994 109776 M720 D E D L S R K M E L P L T P A
Rat Rattus norvegicus P35524 994 110055 T720 D E D V S R K T E L P Q T P T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506417 871 95443 S627 V R E V K F V S A S C T Y R D
Chicken Gallus gallus XP_425521 996 111070 P728 D T D E K A E P Q P P S P S P
Frog Xenopus laevis Q9W701 689 76782 A447 R L V G E T V A L L Y P E G I
Zebra Danio Brachydanio rerio XP_695866 879 96751 G631 G E E N R D K G N R V S E E C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VGH7 1193 133629 A864 E T G S L S P A A S N H E V E
Honey Bee Apis mellifera XP_392015 919 102193 S670 I L K M Q R Q S A N D L T M S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P37020 779 87664 L537 A F M Y I I P L M I V V A I T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 72.4 49.7 N.A. 87.4 87.8 N.A. 63.8 65.8 32.4 56.3 N.A. 34.9 36 N.A. N.A.
Protein Similarity: 100 99.8 72.9 64 N.A. 91.4 91.9 N.A. 71.3 77.1 47.4 68.3 N.A. 51.9 52.4 N.A. N.A.
P-Site Identity: 100 93.3 13.3 13.3 N.A. 66.6 53.3 N.A. 6.6 20 13.3 13.3 N.A. 0 6.6 N.A. N.A.
P-Site Similarity: 100 93.3 13.3 20 N.A. 73.3 73.3 N.A. 20 33.3 20 20 N.A. 20 40 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 37.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 16 0 16 24 8 0 0 8 0 24 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 8 % C
% Asp: 39 0 39 0 0 8 0 0 0 0 8 0 0 0 8 % D
% Glu: 8 39 16 16 16 0 8 0 31 0 0 0 24 8 8 % E
% Phe: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 8 8 0 16 0 16 8 0 0 8 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 0 % H
% Ile: 8 0 0 0 8 8 0 0 0 8 0 0 0 8 8 % I
% Lys: 0 0 8 0 16 0 39 0 0 0 0 0 0 8 0 % K
% Leu: 8 16 0 24 8 0 8 16 8 47 0 24 0 16 0 % L
% Met: 0 0 8 8 0 0 0 8 8 0 0 0 0 8 0 % M
% Asn: 0 0 0 8 0 0 8 0 8 8 8 0 0 0 0 % N
% Pro: 0 0 8 0 0 8 16 8 8 8 47 24 8 24 16 % P
% Gln: 0 0 8 0 8 0 8 0 8 0 8 8 0 0 8 % Q
% Arg: 16 8 0 0 8 24 0 0 0 8 0 0 0 8 0 % R
% Ser: 0 16 0 8 31 8 0 31 0 16 0 16 24 8 8 % S
% Thr: 0 16 0 0 0 8 0 8 0 0 0 8 24 0 16 % T
% Val: 8 0 8 24 8 0 16 0 0 0 16 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 0 8 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _